Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data

Abstract This study investigated incidence and risk factors for venous thromboembolism (VTE) in patients with cervical cancer. We selected 49,514 patients newly diagnosed with cervical cancer from the Korean Health Insurance Review and Assessment Service databases. During the total follow-up period...

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Autores principales:	Jin-Sung Yuk, Banghyun Lee, Myoung Hwan Kim, Kidong Kim, Yong-Soo Seo, Sung Ook Hwang, Yong Kyoon Cho, Yong Beom Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf1402d229d04775af7cdc7247591294
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spelling	oai:doaj.org-article:bf1402d229d04775af7cdc72475912942021-12-02T15:51:16ZIncidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data10.1038/s41598-021-87606-z2045-2322https://doaj.org/article/bf1402d229d04775af7cdc72475912942021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87606-zhttps://doaj.org/toc/2045-2322Abstract This study investigated incidence and risk factors for venous thromboembolism (VTE) in patients with cervical cancer. We selected 49,514 patients newly diagnosed with cervical cancer from the Korean Health Insurance Review and Assessment Service databases. During the total follow-up period and first 6 months after initiation of primary treatments, incidence of VTE, and association of risk factors with VTE occurrence were evaluated according to primary treatments or no treatment, surgery, radiotherapy, and chemotherapy. VTE occurred in 1.15% of patients with cervical cancer. Regardless of the period after initiation of primary treatments, and of VTE, the incidence of thromboembolism was highest in chemotherapy. During the first 12 months, monthly incidence of VTE was highest in chemotherapy and decreased with time in all primary treatments. Compared with no treatment, VTE risk significantly increased for all primary treatments (surgery: HR 1.492; 95% CI 1.186–1.877) (radiotherapy: HR 2.275; 95% CI 1.813–2.855) (chemotherapy: HR 4.378; 95% CI 3.095–6.193) and for chemotherapy during the first 6 months (HR 3.394; 95% CI 2.062–5.588). In this cohort study, incidence and risk of VTE in patients with cervical cancer were the highest when chemotherapy was the primary cancer treatment, and incidence of VTE decreased with time.Jin-Sung YukBanghyun LeeMyoung Hwan KimKidong KimYong-Soo SeoSung Ook HwangYong Kyoon ChoYong Beom KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin-Sung Yuk Banghyun Lee Myoung Hwan Kim Kidong Kim Yong-Soo Seo Sung Ook Hwang Yong Kyoon Cho Yong Beom Kim Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data
description	Abstract This study investigated incidence and risk factors for venous thromboembolism (VTE) in patients with cervical cancer. We selected 49,514 patients newly diagnosed with cervical cancer from the Korean Health Insurance Review and Assessment Service databases. During the total follow-up period and first 6 months after initiation of primary treatments, incidence of VTE, and association of risk factors with VTE occurrence were evaluated according to primary treatments or no treatment, surgery, radiotherapy, and chemotherapy. VTE occurred in 1.15% of patients with cervical cancer. Regardless of the period after initiation of primary treatments, and of VTE, the incidence of thromboembolism was highest in chemotherapy. During the first 12 months, monthly incidence of VTE was highest in chemotherapy and decreased with time in all primary treatments. Compared with no treatment, VTE risk significantly increased for all primary treatments (surgery: HR 1.492; 95% CI 1.186–1.877) (radiotherapy: HR 2.275; 95% CI 1.813–2.855) (chemotherapy: HR 4.378; 95% CI 3.095–6.193) and for chemotherapy during the first 6 months (HR 3.394; 95% CI 2.062–5.588). In this cohort study, incidence and risk of VTE in patients with cervical cancer were the highest when chemotherapy was the primary cancer treatment, and incidence of VTE decreased with time.
format	article
author	Jin-Sung Yuk Banghyun Lee Myoung Hwan Kim Kidong Kim Yong-Soo Seo Sung Ook Hwang Yong Kyoon Cho Yong Beom Kim
author_facet	Jin-Sung Yuk Banghyun Lee Myoung Hwan Kim Kidong Kim Yong-Soo Seo Sung Ook Hwang Yong Kyoon Cho Yong Beom Kim
author_sort	Jin-Sung Yuk
title	Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data
title_short	Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data
title_full	Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data
title_fullStr	Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data
title_full_unstemmed	Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data
title_sort	incidence and risk factors of vte in patients with cervical cancer using the korean national health insurance data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf1402d229d04775af7cdc7247591294
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Incidence and risk factors of VTE in patients with cervical cancer using the Korean national health insurance data

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