Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer

Fibrosis and cancer is described by some epidemiological studies as chronic stages of different disease conditions typically characterized by uncontrolled accumulation of extra-cellular matrix (ECM), thereby leading to inflammation of tissues and organ (lungs, heart, liver and kidney) dysfunction. I...

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Autores principales:	Ebuka-Olisaemeka Nwafor, Peng Lu, Ying Zhang, Rui Liu, Hui Peng, Bin Xing, Yiting Liu, Ziwei Li, Kuibin Zhang, Yukun Zhang, Zhidong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Chlorogenic acid Natural drugs Fibrosis Cancer Epithelial-mesenchymal transition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bf17714ee1d14a9c99b4f5a1a91fb259
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spelling	oai:doaj.org-article:bf17714ee1d14a9c99b4f5a1a91fb2592021-12-02T05:00:22ZChlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer1936-523310.1016/j.tranon.2021.101294https://doaj.org/article/bf17714ee1d14a9c99b4f5a1a91fb2592022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1936523321002850https://doaj.org/toc/1936-5233Fibrosis and cancer is described by some epidemiological studies as chronic stages of different disease conditions typically characterized by uncontrolled accumulation of extra-cellular matrix (ECM), thereby leading to inflammation of tissues and organ (lungs, heart, liver and kidney) dysfunction. It is highly prevalent, and contributes to increased mortality rate worldwide. Currently, the therapeutical approaches involving selected medications (bemcentinib, pirfenidone and nintedanib) obtained synthetically, and used in clinical practices for fibrosis and cancer management and treatment has shown to be unsatisfactorily, especially during progressive stages of the disease. With regards to finding a more potent, effective, and promising curative for fibrosis and cancer, there is need for continuous experimental studies universally. However, phytochemical constituents’ particularly phenolic compounds [Chlorogenic acid (CGA)] obtained from coffee, and coffee beans have been predominantly utilized in experimental studies, due to its multiple pharmacological properties against various disease forms. Considering its natural source alongside minimal toxicity level, CGA, a major precursor of coffee have gained considerable attention nowadays from researchers worldwide, owing to its wide, efficacious and beneficial action against fibrosis and cancer. Interestingly, the safety of CGA has been proven. Furthermore, numerous experimental studies have also deduced massive remarkable outcomes in the use of CGA clinically, as a potential drug candidate against treatment of fibrosis and cancer. In the course of this review article, we systematically discussed the beneficial contributions of CGA with regards to its source, absorption, metabolism, mechanistic effects, and molecular mechanisms against different fibrosis and cancer categorization, which might be a prospective remedy in the future. Moreover, we also highlighted CGA (in vitro and in vivo analytical studies) defensive effects against various disorders.Ebuka-Olisaemeka NwaforPeng LuYing ZhangRui LiuHui PengBin XingYiting LiuZiwei LiKuibin ZhangYukun ZhangZhidong LiuElsevierarticleChlorogenic acidNatural drugsFibrosisCancerEpithelial-mesenchymal transitionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101294- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chlorogenic acid Natural drugs Fibrosis Cancer Epithelial-mesenchymal transition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Chlorogenic acid Natural drugs Fibrosis Cancer Epithelial-mesenchymal transition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ebuka-Olisaemeka Nwafor Peng Lu Ying Zhang Rui Liu Hui Peng Bin Xing Yiting Liu Ziwei Li Kuibin Zhang Yukun Zhang Zhidong Liu Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
description	Fibrosis and cancer is described by some epidemiological studies as chronic stages of different disease conditions typically characterized by uncontrolled accumulation of extra-cellular matrix (ECM), thereby leading to inflammation of tissues and organ (lungs, heart, liver and kidney) dysfunction. It is highly prevalent, and contributes to increased mortality rate worldwide. Currently, the therapeutical approaches involving selected medications (bemcentinib, pirfenidone and nintedanib) obtained synthetically, and used in clinical practices for fibrosis and cancer management and treatment has shown to be unsatisfactorily, especially during progressive stages of the disease. With regards to finding a more potent, effective, and promising curative for fibrosis and cancer, there is need for continuous experimental studies universally. However, phytochemical constituents’ particularly phenolic compounds [Chlorogenic acid (CGA)] obtained from coffee, and coffee beans have been predominantly utilized in experimental studies, due to its multiple pharmacological properties against various disease forms. Considering its natural source alongside minimal toxicity level, CGA, a major precursor of coffee have gained considerable attention nowadays from researchers worldwide, owing to its wide, efficacious and beneficial action against fibrosis and cancer. Interestingly, the safety of CGA has been proven. Furthermore, numerous experimental studies have also deduced massive remarkable outcomes in the use of CGA clinically, as a potential drug candidate against treatment of fibrosis and cancer. In the course of this review article, we systematically discussed the beneficial contributions of CGA with regards to its source, absorption, metabolism, mechanistic effects, and molecular mechanisms against different fibrosis and cancer categorization, which might be a prospective remedy in the future. Moreover, we also highlighted CGA (in vitro and in vivo analytical studies) defensive effects against various disorders.
format	article
author	Ebuka-Olisaemeka Nwafor Peng Lu Ying Zhang Rui Liu Hui Peng Bin Xing Yiting Liu Ziwei Li Kuibin Zhang Yukun Zhang Zhidong Liu
author_facet	Ebuka-Olisaemeka Nwafor Peng Lu Ying Zhang Rui Liu Hui Peng Bin Xing Yiting Liu Ziwei Li Kuibin Zhang Yukun Zhang Zhidong Liu
author_sort	Ebuka-Olisaemeka Nwafor
title	Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
title_short	Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
title_full	Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
title_fullStr	Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
title_full_unstemmed	Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
title_sort	chlorogenic acid: potential source of natural drugs for the therapeutics of fibrosis and cancer
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/bf17714ee1d14a9c99b4f5a1a91fb259
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Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer

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