Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review

Natural products from microbes are a rich source of bioactive molecules to serve as drug leads, predominantly in cancer therapy. Peptides are among the essential nature-derived biomolecules. Owing to their great diversity and favorable characteristics, cyclic peptides (cyclopeptides) from natural so...

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Autor principal:	Linda Sukmarini
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	bioactive anticancer, cyclopeptides, natural products, microbes Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/bf18216571994bfc83330d4e9eb09252
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spelling	oai:doaj.org-article:bf18216571994bfc83330d4e9eb092522021-11-15T06:08:46ZNatural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review2338-94272338-948610.22146/ijp.1270https://doaj.org/article/bf18216571994bfc83330d4e9eb092522021-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1270https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Natural products from microbes are a rich source of bioactive molecules to serve as drug leads, predominantly in cancer therapy. Peptides are among the essential nature-derived biomolecules. Owing to their great diversity and favorable characteristics, cyclic peptides (cyclopeptides) from natural sources have become a propitious lead candidate for the development of therapeutics, including anticancer drugs. This present mini-review highlights cyclopeptides from microbial-derived natural products that have demonstrated significant cytotoxicity or anticancer activities. Moreover, this mini-review also provides a look into the mode of action of anticancer cyclopeptides. Selected examples are given for the potent anticancer cyclopeptides isolated in the recent decade from fungi and bacteria from both terrestrial and marine origins. Naturally occurring cyclopeptides with canonical and non-canonical amino acids isolated from fungi, myxobacteria, actinomycetes, marine cyanobacteria, and microbes associated with marine organisms and their anticancer activity are featured herein.Linda SukmariniUniversitas Gadjah Madaarticlebioactive anticancer, cyclopeptides, natural products, microbesPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 291-303 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioactive anticancer, cyclopeptides, natural products, microbes Pharmacy and materia medica RS1-441
spellingShingle	bioactive anticancer, cyclopeptides, natural products, microbes Pharmacy and materia medica RS1-441 Linda Sukmarini Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review
description	Natural products from microbes are a rich source of bioactive molecules to serve as drug leads, predominantly in cancer therapy. Peptides are among the essential nature-derived biomolecules. Owing to their great diversity and favorable characteristics, cyclic peptides (cyclopeptides) from natural sources have become a propitious lead candidate for the development of therapeutics, including anticancer drugs. This present mini-review highlights cyclopeptides from microbial-derived natural products that have demonstrated significant cytotoxicity or anticancer activities. Moreover, this mini-review also provides a look into the mode of action of anticancer cyclopeptides. Selected examples are given for the potent anticancer cyclopeptides isolated in the recent decade from fungi and bacteria from both terrestrial and marine origins. Naturally occurring cyclopeptides with canonical and non-canonical amino acids isolated from fungi, myxobacteria, actinomycetes, marine cyanobacteria, and microbes associated with marine organisms and their anticancer activity are featured herein.
format	article
author	Linda Sukmarini
author_facet	Linda Sukmarini
author_sort	Linda Sukmarini
title	Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review
title_short	Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review
title_full	Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review
title_fullStr	Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review
title_full_unstemmed	Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review
title_sort	natural bioactive cyclopeptides from microbes as promising anticancer drug leads: a mini-review
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/bf18216571994bfc83330d4e9eb09252
work_keys_str_mv	AT lindasukmarini naturalbioactivecyclopeptidesfrommicrobesaspromisinganticancerdrugleadsaminireview
_version_	1718428579814965248

Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review

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