Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer. Zigang Dong from the University of Minnesota’s Hormel Institute, USA, and colleagues show...

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Autores principales:	Wei He, Eunmiri Roh, Ke Yao, Kangdong Liu, Xing Meng, Fangfang Liu, Penglei Wang, Ann M. Bode, Zigang Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bf1ae206a9c74de2af6655a43c05ce89
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spelling	oai:doaj.org-article:bf1ae206a9c74de2af6655a43c05ce892021-12-02T14:18:30ZTargeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression10.1038/s41698-017-0014-12397-768Xhttps://doaj.org/article/bf1ae206a9c74de2af6655a43c05ce892017-04-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0014-1https://doaj.org/toc/2397-768XEsophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer. Zigang Dong from the University of Minnesota’s Hormel Institute, USA, and colleagues showed that this enzyme, called ornithine decarboxylase (ODC), is expressed at elevated levels in tumor tissues taken from patients with esophageal squamous cell carcinoma. The researchers blocked ODC activity in esophageal cancer cells using either RNA interference techniques or a drug called difluoromethylornithine (DFMO). In both cases, the treatment suppressed further growth and induced cell death. DFMO treatment also reduced the size and weight of tumors in mice implanted with human patient-derived esophageal cancer tissue. The findings point DFMO, which is already used as a medication to treat African sleeping sickness and excessive hair growth, as a potential therapy for cancer patients.Wei HeEunmiri RohKe YaoKangdong LiuXing MengFangfang LiuPenglei WangAnn M. BodeZigang DongNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wei He Eunmiri Roh Ke Yao Kangdong Liu Xing Meng Fangfang Liu Penglei Wang Ann M. Bode Zigang Dong Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
description	Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer. Zigang Dong from the University of Minnesota’s Hormel Institute, USA, and colleagues showed that this enzyme, called ornithine decarboxylase (ODC), is expressed at elevated levels in tumor tissues taken from patients with esophageal squamous cell carcinoma. The researchers blocked ODC activity in esophageal cancer cells using either RNA interference techniques or a drug called difluoromethylornithine (DFMO). In both cases, the treatment suppressed further growth and induced cell death. DFMO treatment also reduced the size and weight of tumors in mice implanted with human patient-derived esophageal cancer tissue. The findings point DFMO, which is already used as a medication to treat African sleeping sickness and excessive hair growth, as a potential therapy for cancer patients.
format	article
author	Wei He Eunmiri Roh Ke Yao Kangdong Liu Xing Meng Fangfang Liu Penglei Wang Ann M. Bode Zigang Dong
author_facet	Wei He Eunmiri Roh Ke Yao Kangdong Liu Xing Meng Fangfang Liu Penglei Wang Ann M. Bode Zigang Dong
author_sort	Wei He
title	Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
title_short	Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
title_full	Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
title_fullStr	Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
title_full_unstemmed	Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
title_sort	targeting ornithine decarboxylase (odc) inhibits esophageal squamous cell carcinoma progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bf1ae206a9c74de2af6655a43c05ce89
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Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

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