Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models

Abstract Rapid switching of applied magnetic fields in the kilohertz frequency range in the human body induces electric fields powerful enough to cause Peripheral Nerve Stimulation (PNS). PNS has become one of the main constraints on the use of high gradient fields for fast imaging with the latest M...

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Autores principales:	Mathias Davids, Bastien Guérin, Matthias Malzacher, Lothar R. Schad, Lawrence L. Wald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf1d3c7dd0c24ca18a11cbe15bbb0753
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spelling	oai:doaj.org-article:bf1d3c7dd0c24ca18a11cbe15bbb07532021-12-02T12:32:37ZPredicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models10.1038/s41598-017-05493-92045-2322https://doaj.org/article/bf1d3c7dd0c24ca18a11cbe15bbb07532017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05493-9https://doaj.org/toc/2045-2322Abstract Rapid switching of applied magnetic fields in the kilohertz frequency range in the human body induces electric fields powerful enough to cause Peripheral Nerve Stimulation (PNS). PNS has become one of the main constraints on the use of high gradient fields for fast imaging with the latest MRI gradient technology. In recent MRI gradients, the applied fields are powerful enough that PNS limits their application in fast imaging sequences like echo-planar imaging. Application of Magnetic Particle Imaging (MPI) to humans is similarly PNS constrained. Despite its role as a major constraint, PNS considerations are only indirectly incorporated in the coil design process, mainly through using the size of the linear region as a proxy for PNS thresholds or by conducting human experiments after constructing coil prototypes. We present for the first time, a framework to simulate PNS thresholds for realistic coil geometries to directly address PNS in the design process. Our PNS model consists of an accurate body model for electromagnetic field simulations, an atlas of peripheral nerves, and a neurodynamic model to predict the nerve responses to imposed electric fields. With this model, we were able to reproduce measured PNS thresholds of two leg/arm solenoid coils with good agreement.Mathias DavidsBastien GuérinMatthias MalzacherLothar R. SchadLawrence L. WaldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mathias Davids Bastien Guérin Matthias Malzacher Lothar R. Schad Lawrence L. Wald Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models
description	Abstract Rapid switching of applied magnetic fields in the kilohertz frequency range in the human body induces electric fields powerful enough to cause Peripheral Nerve Stimulation (PNS). PNS has become one of the main constraints on the use of high gradient fields for fast imaging with the latest MRI gradient technology. In recent MRI gradients, the applied fields are powerful enough that PNS limits their application in fast imaging sequences like echo-planar imaging. Application of Magnetic Particle Imaging (MPI) to humans is similarly PNS constrained. Despite its role as a major constraint, PNS considerations are only indirectly incorporated in the coil design process, mainly through using the size of the linear region as a proxy for PNS thresholds or by conducting human experiments after constructing coil prototypes. We present for the first time, a framework to simulate PNS thresholds for realistic coil geometries to directly address PNS in the design process. Our PNS model consists of an accurate body model for electromagnetic field simulations, an atlas of peripheral nerves, and a neurodynamic model to predict the nerve responses to imposed electric fields. With this model, we were able to reproduce measured PNS thresholds of two leg/arm solenoid coils with good agreement.
format	article
author	Mathias Davids Bastien Guérin Matthias Malzacher Lothar R. Schad Lawrence L. Wald
author_facet	Mathias Davids Bastien Guérin Matthias Malzacher Lothar R. Schad Lawrence L. Wald
author_sort	Mathias Davids
title	Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models
title_short	Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models
title_full	Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models
title_fullStr	Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models
title_full_unstemmed	Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models
title_sort	predicting magnetostimulation thresholds in the peripheral nervous system using realistic body models
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bf1d3c7dd0c24ca18a11cbe15bbb0753
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Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models

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