A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains mark...

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Autores principales:	Gintarė Sendžikaitė, Courtney W. Hanna, Kathleen R. Stewart-Morgan, Elena Ivanova, Gavin Kelsey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf208415af2e4e6986d414cb8d984ae3
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spelling	oai:doaj.org-article:bf208415af2e4e6986d414cb8d984ae32021-12-02T17:01:28ZA DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice10.1038/s41467-019-09713-w2041-1723https://doaj.org/article/bf208415af2e4e6986d414cb8d984ae32019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09713-whttps://doaj.org/toc/2041-1723PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains marked by H3K27me3 in adult tissues.Gintarė SendžikaitėCourtney W. HannaKathleen R. Stewart-MorganElena IvanovaGavin KelseyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gintarė Sendžikaitė Courtney W. Hanna Kathleen R. Stewart-Morgan Elena Ivanova Gavin Kelsey A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
description	PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains marked by H3K27me3 in adult tissues.
format	article
author	Gintarė Sendžikaitė Courtney W. Hanna Kathleen R. Stewart-Morgan Elena Ivanova Gavin Kelsey
author_facet	Gintarė Sendžikaitė Courtney W. Hanna Kathleen R. Stewart-Morgan Elena Ivanova Gavin Kelsey
author_sort	Gintarė Sendžikaitė
title	A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_short	A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_full	A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_fullStr	A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_full_unstemmed	A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_sort	dnmt3a pwwp mutation leads to methylation of bivalent chromatin and growth retardation in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bf208415af2e4e6986d414cb8d984ae3
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A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

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