A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains mark...
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Autores principales: | Gintarė Sendžikaitė, Courtney W. Hanna, Kathleen R. Stewart-Morgan, Elena Ivanova, Gavin Kelsey |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/bf208415af2e4e6986d414cb8d984ae3 |
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