Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene

Polystyrene (PS) is one of the most commonly used thermoplastic materials worldwide and plays a ubiquitous role in today’s biomedical and life science industry and research. The main advantage of PS lies in its facile processability, its excellent optical and mechanical properties, as well as its bi...

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Autores principales:	Markus Mader, Christof Rein, Eveline Konrat, Sophia Lena Meermeyer, Cornelia Lee-Thedieck, Frederik Kotz-Helmer, Bastian E. Rapp
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D printing additive manufacturing fused deposition modeling microfluidics polystyrene cell cultures Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/bf2294f53bc045b7900433e63d674e11
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id	oai:doaj.org-article:bf2294f53bc045b7900433e63d674e11
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spelling	oai:doaj.org-article:bf2294f53bc045b7900433e63d674e112021-11-25T18:23:18ZFused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene10.3390/mi121113482072-666Xhttps://doaj.org/article/bf2294f53bc045b7900433e63d674e112021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1348https://doaj.org/toc/2072-666XPolystyrene (PS) is one of the most commonly used thermoplastic materials worldwide and plays a ubiquitous role in today’s biomedical and life science industry and research. The main advantage of PS lies in its facile processability, its excellent optical and mechanical properties, as well as its biocompatibility. However, PS is only rarely used in microfluidic prototyping, since the structuring of PS is mainly performed using industrial-scale replication processes. So far, microfluidic chips in PS have not been accessible to rapid prototyping via 3D printing. In this work, we present, for the first time, 3D printing of transparent PS using fused deposition modeling (FDM). We present FDM printing of transparent PS microfluidic channels with dimensions as small as 300 µm and a high transparency in the region of interest. Furthermore, we demonstrate the fabrication of functional chips such as Tesla-mixer and mixer cascades. Cell culture experiments showed a high cell viability during seven days of culturing, as well as enabling cell adhesion and proliferation. With the aid of this new PS prototyping method, the development of future biomedical microfluidic chips will be significantly accelerated, as it enables using PS from the early academic prototyping all the way to industrial-scale mass replication.Markus MaderChristof ReinEveline KonratSophia Lena MeermeyerCornelia Lee-ThedieckFrederik Kotz-HelmerBastian E. RappMDPI AGarticle3D printingadditive manufacturingfused deposition modelingmicrofluidicspolystyrenecell culturesMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1348, p 1348 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D printing additive manufacturing fused deposition modeling microfluidics polystyrene cell cultures Mechanical engineering and machinery TJ1-1570
spellingShingle	3D printing additive manufacturing fused deposition modeling microfluidics polystyrene cell cultures Mechanical engineering and machinery TJ1-1570 Markus Mader Christof Rein Eveline Konrat Sophia Lena Meermeyer Cornelia Lee-Thedieck Frederik Kotz-Helmer Bastian E. Rapp Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
description	Polystyrene (PS) is one of the most commonly used thermoplastic materials worldwide and plays a ubiquitous role in today’s biomedical and life science industry and research. The main advantage of PS lies in its facile processability, its excellent optical and mechanical properties, as well as its biocompatibility. However, PS is only rarely used in microfluidic prototyping, since the structuring of PS is mainly performed using industrial-scale replication processes. So far, microfluidic chips in PS have not been accessible to rapid prototyping via 3D printing. In this work, we present, for the first time, 3D printing of transparent PS using fused deposition modeling (FDM). We present FDM printing of transparent PS microfluidic channels with dimensions as small as 300 µm and a high transparency in the region of interest. Furthermore, we demonstrate the fabrication of functional chips such as Tesla-mixer and mixer cascades. Cell culture experiments showed a high cell viability during seven days of culturing, as well as enabling cell adhesion and proliferation. With the aid of this new PS prototyping method, the development of future biomedical microfluidic chips will be significantly accelerated, as it enables using PS from the early academic prototyping all the way to industrial-scale mass replication.
format	article
author	Markus Mader Christof Rein Eveline Konrat Sophia Lena Meermeyer Cornelia Lee-Thedieck Frederik Kotz-Helmer Bastian E. Rapp
author_facet	Markus Mader Christof Rein Eveline Konrat Sophia Lena Meermeyer Cornelia Lee-Thedieck Frederik Kotz-Helmer Bastian E. Rapp
author_sort	Markus Mader
title	Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
title_short	Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
title_full	Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
title_fullStr	Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
title_full_unstemmed	Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
title_sort	fused deposition modeling of microfluidic chips in transparent polystyrene
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf2294f53bc045b7900433e63d674e11
work_keys_str_mv	AT markusmader fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene AT christofrein fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene AT evelinekonrat fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene AT sophialenameermeyer fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene AT cornelialeethedieck fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene AT frederikkotzhelmer fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene AT bastianerapp fuseddepositionmodelingofmicrofluidicchipsintransparentpolystyrene
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Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene

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