Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease

The intestinal microbiota conveys significant benefits to host physiology. Although multiple chronic disorders have been associated with alterations in the intestinal microbiota composition and function, it is still unclear whether these changes are a cause or a consequence. Hence, to translate micr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Silvia Bolsega, André Bleich, Marijana Basic
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	synthetic communities minimal microbiota intestinal microbiota host–microbe interactions gnotobiotic animal models microbiome Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/bf285d0fc9c74ea3a99a8d604026f5fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf285d0fc9c74ea3a99a8d604026f5fe
record_format	dspace
spelling	oai:doaj.org-article:bf285d0fc9c74ea3a99a8d604026f5fe2021-11-25T18:37:19ZSynthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease10.3390/nu131141732072-6643https://doaj.org/article/bf285d0fc9c74ea3a99a8d604026f5fe2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4173https://doaj.org/toc/2072-6643The intestinal microbiota conveys significant benefits to host physiology. Although multiple chronic disorders have been associated with alterations in the intestinal microbiota composition and function, it is still unclear whether these changes are a cause or a consequence. Hence, to translate microbiome research into clinical application, it is necessary to provide a proof of causality of host–microbiota interactions. This is hampered by the complexity of the gut microbiome and many confounding factors. The application of gnotobiotic animal models associated with synthetic communities allows us to address the cause–effect relationship between the host and intestinal microbiota by reducing the microbiome complexity on a manageable level. In recent years, diverse bacterial communities were assembled to analyze the role of microorganisms in infectious, inflammatory, and metabolic diseases. In this review, we outline their application and features. Furthermore, we discuss the differences between human-derived and model-specific communities. Lastly, we highlight the necessity of generating novel synthetic communities to unravel the microbial role associated with specific health outcomes and disease phenotypes. This understanding is essential for the development of novel non-invasive targeted therapeutic strategies to control and modulate intestinal microbiota in health and disease.Silvia BolsegaAndré BleichMarijana BasicMDPI AGarticlesynthetic communitiesminimal microbiotaintestinal microbiotahost–microbe interactionsgnotobiotic animal modelsmicrobiomeNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4173, p 4173 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	synthetic communities minimal microbiota intestinal microbiota host–microbe interactions gnotobiotic animal models microbiome Nutrition. Foods and food supply TX341-641
spellingShingle	synthetic communities minimal microbiota intestinal microbiota host–microbe interactions gnotobiotic animal models microbiome Nutrition. Foods and food supply TX341-641 Silvia Bolsega André Bleich Marijana Basic Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease
description	The intestinal microbiota conveys significant benefits to host physiology. Although multiple chronic disorders have been associated with alterations in the intestinal microbiota composition and function, it is still unclear whether these changes are a cause or a consequence. Hence, to translate microbiome research into clinical application, it is necessary to provide a proof of causality of host–microbiota interactions. This is hampered by the complexity of the gut microbiome and many confounding factors. The application of gnotobiotic animal models associated with synthetic communities allows us to address the cause–effect relationship between the host and intestinal microbiota by reducing the microbiome complexity on a manageable level. In recent years, diverse bacterial communities were assembled to analyze the role of microorganisms in infectious, inflammatory, and metabolic diseases. In this review, we outline their application and features. Furthermore, we discuss the differences between human-derived and model-specific communities. Lastly, we highlight the necessity of generating novel synthetic communities to unravel the microbial role associated with specific health outcomes and disease phenotypes. This understanding is essential for the development of novel non-invasive targeted therapeutic strategies to control and modulate intestinal microbiota in health and disease.
format	article
author	Silvia Bolsega André Bleich Marijana Basic
author_facet	Silvia Bolsega André Bleich Marijana Basic
author_sort	Silvia Bolsega
title	Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease
title_short	Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease
title_full	Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease
title_fullStr	Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease
title_full_unstemmed	Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease
title_sort	synthetic microbiomes on the rise—application in deciphering the role of microbes in host health and disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf285d0fc9c74ea3a99a8d604026f5fe
work_keys_str_mv	AT silviabolsega syntheticmicrobiomesontheriseapplicationindecipheringtheroleofmicrobesinhosthealthanddisease AT andrebleich syntheticmicrobiomesontheriseapplicationindecipheringtheroleofmicrobesinhosthealthanddisease AT marijanabasic syntheticmicrobiomesontheriseapplicationindecipheringtheroleofmicrobesinhosthealthanddisease
_version_	1718410918056951808

Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease

Ejemplares similares