Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma

Dermoscopy is a diagnostic tool widely used in clinical practice for the detection of skin tumors, especially early stages of melanoma. Recent studies have shown that different dermoscopic features are associated with important prognostic parameters of melanoma, such as BRAF mutational status and s...

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Autores principales:	Nika Filipović, Mirna Šitum, Marija Buljan
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	melanoma BRAF sentinel lymph node dermoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/bf28aa8550ad493e96283f3c165561e6
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spelling	oai:doaj.org-article:bf28aa8550ad493e96283f3c165561e62021-11-17T08:27:58ZDermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma10.5826/dpc.1102a402160-9381https://doaj.org/article/bf28aa8550ad493e96283f3c165561e62021-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1529https://doaj.org/toc/2160-9381 Dermoscopy is a diagnostic tool widely used in clinical practice for the detection of skin tumors, especially early stages of melanoma. Recent studies have shown that different dermoscopic features are associated with important prognostic parameters of melanoma, such as BRAF mutational status and sentinel lymph node status. More than half of all melanomas harbor a mutation in the BRAF oncogene. The current management of advanced-stage melanomas is greatly determined by the presence or absence of a mutation in this gene, as targeted therapy with BRAF kinase inhibitors is one of the first therapeutic choices for these patients. Sentinel lymph node status is one of the most significant predictors of a melanoma patient’s survival. Recent studies have shown that different dermoscopic patterns are also associated with sentinel lymph node status. This short article reviews studies that investigated correlations between dermoscopic features, BRAF mutation status and sentinel lymph node status. Nika FilipovićMirna ŠitumMarija BuljanMattioli1885articlemelanomaBRAFsentinel lymph nodedermoscopyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 11, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	melanoma BRAF sentinel lymph node dermoscopy Dermatology RL1-803
spellingShingle	melanoma BRAF sentinel lymph node dermoscopy Dermatology RL1-803 Nika Filipović Mirna Šitum Marija Buljan Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
description	Dermoscopy is a diagnostic tool widely used in clinical practice for the detection of skin tumors, especially early stages of melanoma. Recent studies have shown that different dermoscopic features are associated with important prognostic parameters of melanoma, such as BRAF mutational status and sentinel lymph node status. More than half of all melanomas harbor a mutation in the BRAF oncogene. The current management of advanced-stage melanomas is greatly determined by the presence or absence of a mutation in this gene, as targeted therapy with BRAF kinase inhibitors is one of the first therapeutic choices for these patients. Sentinel lymph node status is one of the most significant predictors of a melanoma patient’s survival. Recent studies have shown that different dermoscopic patterns are also associated with sentinel lymph node status. This short article reviews studies that investigated correlations between dermoscopic features, BRAF mutation status and sentinel lymph node status.
format	article
author	Nika Filipović Mirna Šitum Marija Buljan
author_facet	Nika Filipović Mirna Šitum Marija Buljan
author_sort	Nika Filipović
title	Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
title_short	Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
title_full	Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
title_fullStr	Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
title_full_unstemmed	Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
title_sort	dermoscopic features as predictors of braf mutational status and sentinel lymph node positivity in primary cutaneous melanoma
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/bf28aa8550ad493e96283f3c165561e6
work_keys_str_mv	AT nikafilipovic dermoscopicfeaturesaspredictorsofbrafmutationalstatusandsentinellymphnodepositivityinprimarycutaneousmelanoma AT mirnasitum dermoscopicfeaturesaspredictorsofbrafmutationalstatusandsentinellymphnodepositivityinprimarycutaneousmelanoma AT marijabuljan dermoscopicfeaturesaspredictorsofbrafmutationalstatusandsentinellymphnodepositivityinprimarycutaneousmelanoma
_version_	1718425824666845184

Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma

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