The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor

Abstract This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson’s disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-si...

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Autores principales:	Minji Son, Seung Hwan Han, Chul Hyoung Lyoo, Joo Ae Lim, Jeanhong Jeon, Kee-Bum Hong, Hoon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bf2964903bd4447c831df624fb6c0bfc
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spelling	oai:doaj.org-article:bf2964903bd4447c831df624fb6c0bfc2021-12-02T16:50:28ZThe effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor10.1038/s41531-021-00186-72373-8057https://doaj.org/article/bf2964903bd4447c831df624fb6c0bfc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00186-7https://doaj.org/toc/2373-8057Abstract This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson’s disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-six patients with mild-to-moderate-stage PD who were taking levodopa participated in this study. The Unified Parkinson’s Disease Rating Scale part III (UPDRS III) was used to assess the severity of motor impairment. The Postural Instability and Gait Difficulty (PIGD) subscore was calculated from UPDRS III. Patients were assessed while walking a 20-m corridor in both “OFF” and “ON” levodopa medication states, and gait analysis was performed using inertial sensors. We investigated the changes in gait parameters after taking levodopa and the correlations between UPDRS III, PIGD, and gait parameters. There was a significant improvement in PCI after taking levodopa. No significant effect of levodopa on GA was found. In “OFF” state, PCI and GA were not correlated with UPDRS III and PIGD. However, in “ON” state, PCI was the only gait parameter correlating with UPDRS III, and it was also highly correlated with PIGD compared to other gait parameters. Significant improvement in bilateral-phase coordination was identified in patients with PD after taking levodopa, without significant change in gait symmetricity. Considering the high correlation with UDPRS III and PIGD in “ON” states, PCI may be a useful and quantitative parameter to measure the severity of motor symptoms in PD patients who are on medication.Minji SonSeung Hwan HanChul Hyoung LyooJoo Ae LimJeanhong JeonKee-Bum HongHoon ParkNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Minji Son Seung Hwan Han Chul Hyoung Lyoo Joo Ae Lim Jeanhong Jeon Kee-Bum Hong Hoon Park The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
description	Abstract This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson’s disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-six patients with mild-to-moderate-stage PD who were taking levodopa participated in this study. The Unified Parkinson’s Disease Rating Scale part III (UPDRS III) was used to assess the severity of motor impairment. The Postural Instability and Gait Difficulty (PIGD) subscore was calculated from UPDRS III. Patients were assessed while walking a 20-m corridor in both “OFF” and “ON” levodopa medication states, and gait analysis was performed using inertial sensors. We investigated the changes in gait parameters after taking levodopa and the correlations between UPDRS III, PIGD, and gait parameters. There was a significant improvement in PCI after taking levodopa. No significant effect of levodopa on GA was found. In “OFF” state, PCI and GA were not correlated with UPDRS III and PIGD. However, in “ON” state, PCI was the only gait parameter correlating with UPDRS III, and it was also highly correlated with PIGD compared to other gait parameters. Significant improvement in bilateral-phase coordination was identified in patients with PD after taking levodopa, without significant change in gait symmetricity. Considering the high correlation with UDPRS III and PIGD in “ON” states, PCI may be a useful and quantitative parameter to measure the severity of motor symptoms in PD patients who are on medication.
format	article
author	Minji Son Seung Hwan Han Chul Hyoung Lyoo Joo Ae Lim Jeanhong Jeon Kee-Bum Hong Hoon Park
author_facet	Minji Son Seung Hwan Han Chul Hyoung Lyoo Joo Ae Lim Jeanhong Jeon Kee-Bum Hong Hoon Park
author_sort	Minji Son
title	The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
title_short	The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
title_full	The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
title_fullStr	The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
title_full_unstemmed	The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
title_sort	effect of levodopa on bilateral coordination and gait asymmetry in parkinson’s disease using inertial sensor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf2964903bd4447c831df624fb6c0bfc
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The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor

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