Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease.

Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease.

<h4>Background</h4>Neurodegenerative metabolic disorders such as mucopolysaccharidosis IIIB (MPSIIIB or Sanfilippo disease) accumulate undegraded substrates in the brain and are often unresponsive to enzyme replacement treatments due to the impermeability of the blood brain barrier to en...

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Autores principales: Marcelina Malinowska, Fiona L Wilkinson, Kia J Langford-Smith, Alex Langford-Smith, Jillian R Brown, Brett E Crawford, Marie T Vanier, Grzegorz Grynkiewicz, Rob F Wynn, J Ed Wraith, Grzegorz Wegrzyn, Brian W Bigger
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/bf2a9870d0f24a90bfb8ff75c88c7804
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