THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS

Objective: Mobilized peripheral hematopoietic stem cells are transplanted to cancer patients as support for high-dose chemotherapy. It is believed that the effectiveness of restoring all hematopoietic sprouts during HSC transplantation depends on the total dose of CD34+ cells. At the same time, CD34...

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Autores principales:	Liudmila GRIVTSOVA, Nikolai TUPITSYN
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/bf2ae0a5622d4da98b5caef11d89580e
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spelling	oai:doaj.org-article:bf2ae0a5622d4da98b5caef11d89580e2021-11-10T04:36:53ZTHE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS2531-137910.1016/j.htct.2021.10.1049https://doaj.org/article/bf2ae0a5622d4da98b5caef11d89580e2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011962https://doaj.org/toc/2531-1379Objective: Mobilized peripheral hematopoietic stem cells are transplanted to cancer patients as support for high-dose chemotherapy. It is believed that the effectiveness of restoring all hematopoietic sprouts during HSC transplantation depends on the total dose of CD34+ cells. At the same time, CD34+ stem cells are a heterogeneous cell pool, including progenitor cells of different levels of differentiation and different ability to proliferate. Accordingly, it can be expected that the subpopulation composit. Methodology: We have studied of HSC subsets in 569 specimens of hemopoietic tissue (blood cells and LP cells) from 167 adult cancer patients and on 557 specimens of hemopoietic tissue from 263 pediatric cancer patients. Also, 61 samples of LP from 50 healthy HSC donors were studied. All patients were managed at bone marrow transplantation units of hematology malignancy and oncology department of N.N. Blokhin Cancer Research Center from 1996 to 2014. Results: Peripheral hemopoietic stem cells (HSC) that are transplanted to cancer patients to reduce critical pancytopenia vary in subset composition and include early polypotent precursors (CD38- and/or HLA-DR-, CD90+, CD45-negative), lymphoid precursors (CD10+, CD7+, CD2+, CD19+, CD56+), megakaryocyte- (CD61+) and myeloid-committed precursors (CD117+, CD13+, CD33+). These subsets of early and committed HSC are found in different proportions in cancer patients and normal donors. Conclusion: So, the pool of mobilized HSC is heterogeneous and represented by pluripotent precursors and committed HSC in different proportions that are in variable, rather sophisticated interrelations. Mobilization effect of SC individual subsets is related with disease type. To achieve fast recovery of granulocyte lineages after HSC autologous or allogeneic transplantation one should not focus only on proportion of committed myeloid HSC: optimal HSC content to be transplanted should be in a certain balance.Liudmila GRIVTSOVANikolai TUPITSYNElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S47-S48 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Liudmila GRIVTSOVA Nikolai TUPITSYN THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS
description	Objective: Mobilized peripheral hematopoietic stem cells are transplanted to cancer patients as support for high-dose chemotherapy. It is believed that the effectiveness of restoring all hematopoietic sprouts during HSC transplantation depends on the total dose of CD34+ cells. At the same time, CD34+ stem cells are a heterogeneous cell pool, including progenitor cells of different levels of differentiation and different ability to proliferate. Accordingly, it can be expected that the subpopulation composit. Methodology: We have studied of HSC subsets in 569 specimens of hemopoietic tissue (blood cells and LP cells) from 167 adult cancer patients and on 557 specimens of hemopoietic tissue from 263 pediatric cancer patients. Also, 61 samples of LP from 50 healthy HSC donors were studied. All patients were managed at bone marrow transplantation units of hematology malignancy and oncology department of N.N. Blokhin Cancer Research Center from 1996 to 2014. Results: Peripheral hemopoietic stem cells (HSC) that are transplanted to cancer patients to reduce critical pancytopenia vary in subset composition and include early polypotent precursors (CD38- and/or HLA-DR-, CD90+, CD45-negative), lymphoid precursors (CD10+, CD7+, CD2+, CD19+, CD56+), megakaryocyte- (CD61+) and myeloid-committed precursors (CD117+, CD13+, CD33+). These subsets of early and committed HSC are found in different proportions in cancer patients and normal donors. Conclusion: So, the pool of mobilized HSC is heterogeneous and represented by pluripotent precursors and committed HSC in different proportions that are in variable, rather sophisticated interrelations. Mobilization effect of SC individual subsets is related with disease type. To achieve fast recovery of granulocyte lineages after HSC autologous or allogeneic transplantation one should not focus only on proportion of committed myeloid HSC: optimal HSC content to be transplanted should be in a certain balance.
format	article
author	Liudmila GRIVTSOVA Nikolai TUPITSYN
author_facet	Liudmila GRIVTSOVA Nikolai TUPITSYN
author_sort	Liudmila GRIVTSOVA
title	THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS
title_short	THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS
title_full	THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS
title_fullStr	THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS
title_full_unstemmed	THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS
title_sort	role of subpopulations of mobilized peripheral hematopoietic stem cells in the restoration of hematopoiesis during high-dose chemotherapy in cancer patients
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bf2ae0a5622d4da98b5caef11d89580e
work_keys_str_mv	AT liudmilagrivtsova theroleofsubpopulationsofmobilizedperipheralhematopoieticstemcellsintherestorationofhematopoiesisduringhighdosechemotherapyincancerpatients AT nikolaitupitsyn theroleofsubpopulationsofmobilizedperipheralhematopoieticstemcellsintherestorationofhematopoiesisduringhighdosechemotherapyincancerpatients AT liudmilagrivtsova roleofsubpopulationsofmobilizedperipheralhematopoieticstemcellsintherestorationofhematopoiesisduringhighdosechemotherapyincancerpatients AT nikolaitupitsyn roleofsubpopulationsofmobilizedperipheralhematopoieticstemcellsintherestorationofhematopoiesisduringhighdosechemotherapyincancerpatients
_version_	1718440593889165312

THE ROLE OF SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN THE RESTORATION OF HEMATOPOIESIS DURING HIGH-DOSE CHEMOTHERAPY IN CANCER PATIENTS

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