Metastatic progression is associated with dynamic changes in the local microenvironment

Metastatic colonization—the growth of single metastatic cells or small lesions into gross metastases—is poorly understood. Here, the authors characterize the natural history of metastatic growth and assess the impact of chemotherapy in an autochthonous model of pancreatic cancer.

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Autores principales:	Nicole M. Aiello, David L. Bajor, Robert J. Norgard, Amine Sahmoud, Neha Bhagwat, Minh N. Pham, Toby C. Cornish, Christine A. Iacobuzio-Donahue, Robert H. Vonderheide, Ben Z. Stanger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf2c2323822742288d632d0fd9cd990d
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spelling	oai:doaj.org-article:bf2c2323822742288d632d0fd9cd990d2021-12-02T14:39:12ZMetastatic progression is associated with dynamic changes in the local microenvironment10.1038/ncomms128192041-1723https://doaj.org/article/bf2c2323822742288d632d0fd9cd990d2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12819https://doaj.org/toc/2041-1723Metastatic colonization—the growth of single metastatic cells or small lesions into gross metastases—is poorly understood. Here, the authors characterize the natural history of metastatic growth and assess the impact of chemotherapy in an autochthonous model of pancreatic cancer.Nicole M. AielloDavid L. BajorRobert J. NorgardAmine SahmoudNeha BhagwatMinh N. PhamToby C. CornishChristine A. Iacobuzio-DonahueRobert H. VonderheideBen Z. StangerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicole M. Aiello David L. Bajor Robert J. Norgard Amine Sahmoud Neha Bhagwat Minh N. Pham Toby C. Cornish Christine A. Iacobuzio-Donahue Robert H. Vonderheide Ben Z. Stanger Metastatic progression is associated with dynamic changes in the local microenvironment
description	Metastatic colonization—the growth of single metastatic cells or small lesions into gross metastases—is poorly understood. Here, the authors characterize the natural history of metastatic growth and assess the impact of chemotherapy in an autochthonous model of pancreatic cancer.
format	article
author	Nicole M. Aiello David L. Bajor Robert J. Norgard Amine Sahmoud Neha Bhagwat Minh N. Pham Toby C. Cornish Christine A. Iacobuzio-Donahue Robert H. Vonderheide Ben Z. Stanger
author_facet	Nicole M. Aiello David L. Bajor Robert J. Norgard Amine Sahmoud Neha Bhagwat Minh N. Pham Toby C. Cornish Christine A. Iacobuzio-Donahue Robert H. Vonderheide Ben Z. Stanger
author_sort	Nicole M. Aiello
title	Metastatic progression is associated with dynamic changes in the local microenvironment
title_short	Metastatic progression is associated with dynamic changes in the local microenvironment
title_full	Metastatic progression is associated with dynamic changes in the local microenvironment
title_fullStr	Metastatic progression is associated with dynamic changes in the local microenvironment
title_full_unstemmed	Metastatic progression is associated with dynamic changes in the local microenvironment
title_sort	metastatic progression is associated with dynamic changes in the local microenvironment
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bf2c2323822742288d632d0fd9cd990d
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Metastatic progression is associated with dynamic changes in the local microenvironment

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