Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort

Abstract Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely st...

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Autores principales:	Benedikte Paulsen, Olga V. Gran, Marianne T. Severinsen, Jens Hammerstrøm, Søren R. Kristensen, Suzanne C. Cannegieter, Hanne Skille, Anne Tjønneland, Frits R. Rosendaal, Kim Overvad, Inger Anne Næss, John-Bjarne Hansen, Sigrid K. Brækkan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf2cdfde167248c2ba6840af71eaf77b
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spelling	oai:doaj.org-article:bf2cdfde167248c2ba6840af71eaf77b2021-12-02T15:14:55ZAssociation of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort10.1038/s41598-021-98062-02045-2322https://doaj.org/article/bf2cdfde167248c2ba6840af71eaf77b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98062-0https://doaj.org/toc/2045-2322Abstract Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely studied. We aimed to investigate the association between smoking and VTE in subjects with and without cancer in a large population-based cohort. The Scandinavian Thrombosis and Cancer (STAC) cohort included 144,952 participants followed from 1993–1997 to 2008–2012. Information on smoking habits was derived from self-administered questionnaires. Active cancer was defined as the first two years following the date of cancer diagnosis. Former smokers (n = 35,890) and those with missing information on smoking status (n = 3680) at baseline were excluded. During a mean follow up of 11 years, 10,181 participants were diagnosed with cancer, and 1611 developed incident VTE, of which 214 were cancer-related. Smoking was associated with a 50% increased risk of VTE (HR 1.49, 95% CI 1.12–1.98) in cancer patients, whereas no association was found in cancer-free subjects (HR 1.07, 95% CI 0.96–1.20). In cancer patients, the risk of VTE among smokers remained unchanged after adjustment for cancer site and metastasis. Stratified analyses showed that smoking was a risk factor for VTE among those with smoking-related and advanced cancers. In conclusion, smoking was associated with increased VTE risk in subjects with active cancer, but not in those without cancer. Our findings imply a biological interaction between cancer and smoking on the risk of VTE.Benedikte PaulsenOlga V. GranMarianne T. SeverinsenJens HammerstrømSøren R. KristensenSuzanne C. CannegieterHanne SkilleAnne TjønnelandFrits R. RosendaalKim OvervadInger Anne NæssJohn-Bjarne HansenSigrid K. BrækkanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benedikte Paulsen Olga V. Gran Marianne T. Severinsen Jens Hammerstrøm Søren R. Kristensen Suzanne C. Cannegieter Hanne Skille Anne Tjønneland Frits R. Rosendaal Kim Overvad Inger Anne Næss John-Bjarne Hansen Sigrid K. Brækkan Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
description	Abstract Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely studied. We aimed to investigate the association between smoking and VTE in subjects with and without cancer in a large population-based cohort. The Scandinavian Thrombosis and Cancer (STAC) cohort included 144,952 participants followed from 1993–1997 to 2008–2012. Information on smoking habits was derived from self-administered questionnaires. Active cancer was defined as the first two years following the date of cancer diagnosis. Former smokers (n = 35,890) and those with missing information on smoking status (n = 3680) at baseline were excluded. During a mean follow up of 11 years, 10,181 participants were diagnosed with cancer, and 1611 developed incident VTE, of which 214 were cancer-related. Smoking was associated with a 50% increased risk of VTE (HR 1.49, 95% CI 1.12–1.98) in cancer patients, whereas no association was found in cancer-free subjects (HR 1.07, 95% CI 0.96–1.20). In cancer patients, the risk of VTE among smokers remained unchanged after adjustment for cancer site and metastasis. Stratified analyses showed that smoking was a risk factor for VTE among those with smoking-related and advanced cancers. In conclusion, smoking was associated with increased VTE risk in subjects with active cancer, but not in those without cancer. Our findings imply a biological interaction between cancer and smoking on the risk of VTE.
format	article
author	Benedikte Paulsen Olga V. Gran Marianne T. Severinsen Jens Hammerstrøm Søren R. Kristensen Suzanne C. Cannegieter Hanne Skille Anne Tjønneland Frits R. Rosendaal Kim Overvad Inger Anne Næss John-Bjarne Hansen Sigrid K. Brækkan
author_facet	Benedikte Paulsen Olga V. Gran Marianne T. Severinsen Jens Hammerstrøm Søren R. Kristensen Suzanne C. Cannegieter Hanne Skille Anne Tjønneland Frits R. Rosendaal Kim Overvad Inger Anne Næss John-Bjarne Hansen Sigrid K. Brækkan
author_sort	Benedikte Paulsen
title	Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
title_short	Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
title_full	Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
title_fullStr	Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
title_full_unstemmed	Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
title_sort	association of smoking and cancer with the risk of venous thromboembolism: the scandinavian thrombosis and cancer cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf2cdfde167248c2ba6840af71eaf77b
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Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort

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