Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging

Yi Liu,1,* Hua Xiong,2,3,* Xiaojiao Li,2,3 Dan Zhang,2,3 Chao Yang,2,3 Jiayi Yu,2,3 Ruikun Liao,2,3 Bi Zhou,2,3 Xianlong Huang,2,3 Zhuoyue Tang2,3 1Department of Radiology, Peking University First Hospital, Beijing 100034, People’s Republic of China; 2Department of Radiology, Chongqing Gen...

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Autores principales:	Liu Y, Xiong H, Li X, Zhang D, Yang C, Yu J, Liao R, Zhou B, Huang X, Tang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	neuromyelitis optica magnetic resonance imaging resting-state functional magnetic resonance imaging (rs-fmri) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bf3555855e7f404ea3b58da9ab386efd
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spelling	oai:doaj.org-article:bf3555855e7f404ea3b58da9ab386efd2021-12-02T09:07:52ZAbnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging1178-2021https://doaj.org/article/bf3555855e7f404ea3b58da9ab386efd2020-01-01T00:00:00Zhttps://www.dovepress.com/abnormal-baseline-brain-activity-in-neuromyelitis-optica-patients-with-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yi Liu,1,* Hua Xiong,2,3,* Xiaojiao Li,2,3 Dan Zhang,2,3 Chao Yang,2,3 Jiayi Yu,2,3 Ruikun Liao,2,3 Bi Zhou,2,3 Xianlong Huang,2,3 Zhuoyue Tang2,3 1Department of Radiology, Peking University First Hospital, Beijing 100034, People’s Republic of China; 2Department of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, People’s Republic of China; 3Molecular and Functional Imaging Laboratory, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhuoyue TangDepartment of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 104 Pipashan Main Street, Yuzhong District, Chongqing 400014, People’s Republic of ChinaEmail zhuoyue_tang@ucas.ac.cnObjective: To investigate the baseline brain activity in neuromyelitis optica patients without brain lesion using the regional amplitude of low-frequency ﬂuctuation (ALFF) and fractional amplitude of low-frequency ﬂuctuation (fALFF) as indexes.Materials and methods: Forty-two patients of NMO with normal performance in conventional MRI and 42 healthy controls, matched in gender and age, were enrolled in this study. Resting-state functional magnetic resonance imaging (rs-fMRI) data acquired using the rs-fMRI Data Analysis Toolkit. The relationships between expanded disability states scale (EDSS) scores, abnormal baseline brain activity and disease duration were explored.Results: The left inferior temporal, left cerebellum_4_5, bilateral superior temporal pole, left caudate, right superior temporal, left middle frontal and left superior occipital showed significantly increased ALFF in the NMO. Regions of abnormal fALFF were similar to those of ALFF except that increased fALFF were also indicated in the right cerebellum crus2, right hippocampus, left parahippocampal gyrus and left supplementary motor area. Furthermore, a significant correlation between EDSS scores and ALFF/fALFF was noted in the left inferior temporal gyrus.Conclusion: Results confirmed the disturbances in NMO-related neural networks, which probably be related to spinal cord damage.Keywords: neuromyelitis optica, magnetic resonance imaging, resting-state functional magnetic resonance imaging, rs-fMRILiu YXiong HLi XZhang DYang CYu JLiao RZhou BHuang XTang ZDove Medical Pressarticleneuromyelitis opticamagnetic resonance imagingresting-state functional magnetic resonance imaging (rs-fmri)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 71-79 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuromyelitis optica magnetic resonance imaging resting-state functional magnetic resonance imaging (rs-fmri) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	neuromyelitis optica magnetic resonance imaging resting-state functional magnetic resonance imaging (rs-fmri) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu Y Xiong H Li X Zhang D Yang C Yu J Liao R Zhou B Huang X Tang Z Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging
description	Yi Liu,1,* Hua Xiong,2,3,* Xiaojiao Li,2,3 Dan Zhang,2,3 Chao Yang,2,3 Jiayi Yu,2,3 Ruikun Liao,2,3 Bi Zhou,2,3 Xianlong Huang,2,3 Zhuoyue Tang2,3 1Department of Radiology, Peking University First Hospital, Beijing 100034, People’s Republic of China; 2Department of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, People’s Republic of China; 3Molecular and Functional Imaging Laboratory, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhuoyue TangDepartment of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 104 Pipashan Main Street, Yuzhong District, Chongqing 400014, People’s Republic of ChinaEmail zhuoyue_tang@ucas.ac.cnObjective: To investigate the baseline brain activity in neuromyelitis optica patients without brain lesion using the regional amplitude of low-frequency ﬂuctuation (ALFF) and fractional amplitude of low-frequency ﬂuctuation (fALFF) as indexes.Materials and methods: Forty-two patients of NMO with normal performance in conventional MRI and 42 healthy controls, matched in gender and age, were enrolled in this study. Resting-state functional magnetic resonance imaging (rs-fMRI) data acquired using the rs-fMRI Data Analysis Toolkit. The relationships between expanded disability states scale (EDSS) scores, abnormal baseline brain activity and disease duration were explored.Results: The left inferior temporal, left cerebellum_4_5, bilateral superior temporal pole, left caudate, right superior temporal, left middle frontal and left superior occipital showed significantly increased ALFF in the NMO. Regions of abnormal fALFF were similar to those of ALFF except that increased fALFF were also indicated in the right cerebellum crus2, right hippocampus, left parahippocampal gyrus and left supplementary motor area. Furthermore, a significant correlation between EDSS scores and ALFF/fALFF was noted in the left inferior temporal gyrus.Conclusion: Results confirmed the disturbances in NMO-related neural networks, which probably be related to spinal cord damage.Keywords: neuromyelitis optica, magnetic resonance imaging, resting-state functional magnetic resonance imaging, rs-fMRI
format	article
author	Liu Y Xiong H Li X Zhang D Yang C Yu J Liao R Zhou B Huang X Tang Z
author_facet	Liu Y Xiong H Li X Zhang D Yang C Yu J Liao R Zhou B Huang X Tang Z
author_sort	Liu Y
title	Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging
title_short	Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging
title_full	Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging
title_fullStr	Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging
title_full_unstemmed	Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging
title_sort	abnormal baseline brain activity in neuromyelitis optica patients without brain lesion detected by resting-state functional magnetic resonance imaging
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bf3555855e7f404ea3b58da9ab386efd
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Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging

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