Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin

Photocaged molecules have advantages in terms of temporal and spatial control compared to conventional pharmacological compounds. The authors present a synthetic saxitoxin derivative affixed to a photocleavable group for precise modulation of Na channels.

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Autores principales:	Anna V. Elleman, Gabrielle Devienne, Christopher D. Makinson, Allison L. Haynes, John R. Huguenard, J. Du Bois
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf380589f814439eb42a94b2247df74e
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spelling	oai:doaj.org-article:bf380589f814439eb42a94b2247df74e2021-12-02T18:34:15ZPrecise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin10.1038/s41467-021-24392-22041-1723https://doaj.org/article/bf380589f814439eb42a94b2247df74e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24392-2https://doaj.org/toc/2041-1723Photocaged molecules have advantages in terms of temporal and spatial control compared to conventional pharmacological compounds. The authors present a synthetic saxitoxin derivative affixed to a photocleavable group for precise modulation of Na channels.Anna V. EllemanGabrielle DevienneChristopher D. MakinsonAllison L. HaynesJohn R. HuguenardJ. Du BoisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna V. Elleman Gabrielle Devienne Christopher D. Makinson Allison L. Haynes John R. Huguenard J. Du Bois Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
description	Photocaged molecules have advantages in terms of temporal and spatial control compared to conventional pharmacological compounds. The authors present a synthetic saxitoxin derivative affixed to a photocleavable group for precise modulation of Na channels.
format	article
author	Anna V. Elleman Gabrielle Devienne Christopher D. Makinson Allison L. Haynes John R. Huguenard J. Du Bois
author_facet	Anna V. Elleman Gabrielle Devienne Christopher D. Makinson Allison L. Haynes John R. Huguenard J. Du Bois
author_sort	Anna V. Elleman
title	Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
title_short	Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
title_full	Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
title_fullStr	Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
title_full_unstemmed	Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
title_sort	precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf380589f814439eb42a94b2247df74e
work_keys_str_mv	AT annavelleman precisespatiotemporalcontrolofvoltagegatedsodiumchannelsbyphotocagedsaxitoxin AT gabrielledevienne precisespatiotemporalcontrolofvoltagegatedsodiumchannelsbyphotocagedsaxitoxin AT christopherdmakinson precisespatiotemporalcontrolofvoltagegatedsodiumchannelsbyphotocagedsaxitoxin AT allisonlhaynes precisespatiotemporalcontrolofvoltagegatedsodiumchannelsbyphotocagedsaxitoxin AT johnrhuguenard precisespatiotemporalcontrolofvoltagegatedsodiumchannelsbyphotocagedsaxitoxin AT jdubois precisespatiotemporalcontrolofvoltagegatedsodiumchannelsbyphotocagedsaxitoxin
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Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin

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