Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology

Abstract In recent decades, herbal medicines have played more and more important roles in the healthcare system in the world because of the good efficacy. However, with the increasing use of herbal medicines, the toxicity induced by herbal medicines has become a global issue. Therefore, it is needed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wuwen Feng, Juan Liu, Dandan Zhang, Yuzhu Tan, Hao Cheng, Cheng Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf3861ebef9f4a7aac98270d1ac3d588
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf3861ebef9f4a7aac98270d1ac3d588
record_format	dspace
spelling	oai:doaj.org-article:bf3861ebef9f4a7aac98270d1ac3d5882021-12-05T12:12:00ZRevealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology10.1038/s41598-021-02167-52045-2322https://doaj.org/article/bf3861ebef9f4a7aac98270d1ac3d5882021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02167-5https://doaj.org/toc/2045-2322Abstract In recent decades, herbal medicines have played more and more important roles in the healthcare system in the world because of the good efficacy. However, with the increasing use of herbal medicines, the toxicity induced by herbal medicines has become a global issue. Therefore, it is needed to investigate the mechanism behind the efficacy and toxicity of herbal medicines. In this study, using Aconiti Lateralis Radix Praeparata (Fuzi) as an example, we adopted a systems pharmacology approach to investigate the mechanism of Fuzi in treating rheumatoid arthritis and in inducing cardiac toxicity and neurotoxicity. The results showed that Fuzi has 25 bioactive compounds that act holistically on 61 targets and 27 pathways to treat rheumatoid arthritis, and modulation of inflammation state is one of the main mechanisms of Fuzi. In addition, the toxicity of Fuzi is linked to 32 compounds that act on 187 targets and 4 pathways, and the targets and pathways can directly modulate the flow of Na+, Ca2+, and K+. We also found out that non-toxic compounds such as myristic acid can act on targets of toxic compounds and therefore may influence the toxicity. The results not only reveal the efficacy and toxicity mechanism of Fuzi, but also add new concept for understanding the toxicity of herbal medicines, i.e., the compounds that are not directly toxic may influence the toxicity as well.Wuwen FengJuan LiuDandan ZhangYuzhu TanHao ChengCheng PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wuwen Feng Juan Liu Dandan Zhang Yuzhu Tan Hao Cheng Cheng Peng Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology
description	Abstract In recent decades, herbal medicines have played more and more important roles in the healthcare system in the world because of the good efficacy. However, with the increasing use of herbal medicines, the toxicity induced by herbal medicines has become a global issue. Therefore, it is needed to investigate the mechanism behind the efficacy and toxicity of herbal medicines. In this study, using Aconiti Lateralis Radix Praeparata (Fuzi) as an example, we adopted a systems pharmacology approach to investigate the mechanism of Fuzi in treating rheumatoid arthritis and in inducing cardiac toxicity and neurotoxicity. The results showed that Fuzi has 25 bioactive compounds that act holistically on 61 targets and 27 pathways to treat rheumatoid arthritis, and modulation of inflammation state is one of the main mechanisms of Fuzi. In addition, the toxicity of Fuzi is linked to 32 compounds that act on 187 targets and 4 pathways, and the targets and pathways can directly modulate the flow of Na+, Ca2+, and K+. We also found out that non-toxic compounds such as myristic acid can act on targets of toxic compounds and therefore may influence the toxicity. The results not only reveal the efficacy and toxicity mechanism of Fuzi, but also add new concept for understanding the toxicity of herbal medicines, i.e., the compounds that are not directly toxic may influence the toxicity as well.
format	article
author	Wuwen Feng Juan Liu Dandan Zhang Yuzhu Tan Hao Cheng Cheng Peng
author_facet	Wuwen Feng Juan Liu Dandan Zhang Yuzhu Tan Hao Cheng Cheng Peng
author_sort	Wuwen Feng
title	Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology
title_short	Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology
title_full	Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology
title_fullStr	Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology
title_full_unstemmed	Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology
title_sort	revealing the efficacy-toxicity relationship of fuzi in treating rheumatoid arthritis by systems pharmacology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf3861ebef9f4a7aac98270d1ac3d588
work_keys_str_mv	AT wuwenfeng revealingtheefficacytoxicityrelationshipoffuziintreatingrheumatoidarthritisbysystemspharmacology AT juanliu revealingtheefficacytoxicityrelationshipoffuziintreatingrheumatoidarthritisbysystemspharmacology AT dandanzhang revealingtheefficacytoxicityrelationshipoffuziintreatingrheumatoidarthritisbysystemspharmacology AT yuzhutan revealingtheefficacytoxicityrelationshipoffuziintreatingrheumatoidarthritisbysystemspharmacology AT haocheng revealingtheefficacytoxicityrelationshipoffuziintreatingrheumatoidarthritisbysystemspharmacology AT chengpeng revealingtheefficacytoxicityrelationshipoffuziintreatingrheumatoidarthritisbysystemspharmacology
_version_	1718372156047360000

Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology

Ejemplares similares