Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment

Luká&scaron; Zachar, Darina Bačenková, Ján Rosocha Associated Tissue Bank of Faculty of Medicine of P. J. &Scaron;afárik University and University Hospital of L. Pasteur, Ko&scaron;ice, Slovak Republic Abstract: Human mesench...

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Autores principales:	Zachar L, Bačenková D, Rosocha J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	mesenchymal stem cells immunomodulation bioactive factors homing inflammatory environment Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/bf38f2210a514a959793bb1387a776c2
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spelling	oai:doaj.org-article:bf38f2210a514a959793bb1387a776c22021-12-02T04:24:13ZActivation, homing, and role of the mesenchymal stem cells in the inflammatory environment1178-7031https://doaj.org/article/bf38f2210a514a959793bb1387a776c22016-12-01T00:00:00Zhttps://www.dovepress.com/activation-homing-and-role-of-the-mesenchymal-stem-cells-in-the-inflam-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Luká&scaron; Zachar, Darina Bačenková, Ján Rosocha Associated Tissue Bank of Faculty of Medicine of P. J. &Scaron;afárik University and University Hospital of L. Pasteur, Ko&scaron;ice, Slovak Republic Abstract: Human mesenchymal stem cells (MSCs) are considered to be a promising source of cells in regenerative medicine. They have large potential to differentiate into various tissue-specific populations and may be isolated from diverse tissues in desired quantities. As cells of potential autologous origin, they allow recipients to avoid the alloantigen responses. They also have the ability to create immunomodulatory microenvironment, and thus help to minimize organ damage caused by the inflammation and cells activated by the immune system. Our knowledge about the reparative, regenerative, and immunomodulatory properties of MSCs is advancing. At present, there is a very comprehensible idea on how MSCs affect the immune system, particularly in relation to the tissue and organ damage on immunological basis. Hitherto a number of effective mechanisms have been described by which MSCs influence the immune responses. These mechanisms include a secretion of soluble bioactive agents, an induction of regulatory T cells, modulation of tolerogenic dendritic cells, as well as induction of anergy and apoptosis. MSCs are thus able to influence both innate and adaptive immune responses. Soluble factors that are released into local microenvironment with their subsequent paracrine effects are keys to the activation. As a result, activated MSCs contribute to the restoration of damaged tissues or organs through various mechanisms facilitating reparative and regenerative processes as well as through immunomodulation itself and differentiation into the cells of the target tissue. Keywords: stem cells, migration, bioactive factors, immunomodulatory microenvironment, regulatory T cells, tissue regeneration Zachar LBačenková DRosocha JDove Medical Pressarticlemesenchymal stem cellsimmunomodulationbioactive factorshominginflammatory environmentPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 9, Pp 231-240 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells immunomodulation bioactive factors homing inflammatory environment Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	mesenchymal stem cells immunomodulation bioactive factors homing inflammatory environment Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zachar L Bačenková D Rosocha J Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
description	Luká&scaron; Zachar, Darina Bačenková, Ján Rosocha Associated Tissue Bank of Faculty of Medicine of P. J. &Scaron;afárik University and University Hospital of L. Pasteur, Ko&scaron;ice, Slovak Republic Abstract: Human mesenchymal stem cells (MSCs) are considered to be a promising source of cells in regenerative medicine. They have large potential to differentiate into various tissue-specific populations and may be isolated from diverse tissues in desired quantities. As cells of potential autologous origin, they allow recipients to avoid the alloantigen responses. They also have the ability to create immunomodulatory microenvironment, and thus help to minimize organ damage caused by the inflammation and cells activated by the immune system. Our knowledge about the reparative, regenerative, and immunomodulatory properties of MSCs is advancing. At present, there is a very comprehensible idea on how MSCs affect the immune system, particularly in relation to the tissue and organ damage on immunological basis. Hitherto a number of effective mechanisms have been described by which MSCs influence the immune responses. These mechanisms include a secretion of soluble bioactive agents, an induction of regulatory T cells, modulation of tolerogenic dendritic cells, as well as induction of anergy and apoptosis. MSCs are thus able to influence both innate and adaptive immune responses. Soluble factors that are released into local microenvironment with their subsequent paracrine effects are keys to the activation. As a result, activated MSCs contribute to the restoration of damaged tissues or organs through various mechanisms facilitating reparative and regenerative processes as well as through immunomodulation itself and differentiation into the cells of the target tissue. Keywords: stem cells, migration, bioactive factors, immunomodulatory microenvironment, regulatory T cells, tissue regeneration
format	article
author	Zachar L Bačenková D Rosocha J
author_facet	Zachar L Bačenková D Rosocha J
author_sort	Zachar L
title	Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
title_short	Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
title_full	Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
title_fullStr	Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
title_full_unstemmed	Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
title_sort	activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/bf38f2210a514a959793bb1387a776c2
work_keys_str_mv	AT zacharl activationhomingandroleofthemesenchymalstemcellsintheinflammatoryenvironment AT bacenkovad activationhomingandroleofthemesenchymalstemcellsintheinflammatoryenvironment AT rosochaj activationhomingandroleofthemesenchymalstemcellsintheinflammatoryenvironment
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Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment

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