A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al. develop a cGMP sensor mouse to follow cGMP dynamics in platelets, and find that shear stress activates NO-c...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lai Wen, Susanne Feil, Markus Wolters, Martin Thunemann, Frank Regler, Kjestine Schmidt, Andreas Friebe, Marcus Olbrich, Harald Langer, Meinrad Gawaz, Cor de Wit, Robert Feil
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/bf3cc56a77f94f498614de8a9375ba7c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:bf3cc56a77f94f498614de8a9375ba7c
record_format dspace
spelling oai:doaj.org-article:bf3cc56a77f94f498614de8a9375ba7c2021-12-02T16:49:24ZA shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis10.1038/s41467-018-06638-82041-1723https://doaj.org/article/bf3cc56a77f94f498614de8a9375ba7c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06638-8https://doaj.org/toc/2041-1723Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al. develop a cGMP sensor mouse to follow cGMP dynamics in platelets, and find that shear stress activates NO-cGMP-cGKI signaling during platelet aggregation to limit thrombosis.Lai WenSusanne FeilMarkus WoltersMartin ThunemannFrank ReglerKjestine SchmidtAndreas FriebeMarcus OlbrichHarald LangerMeinrad GawazCor de WitRobert FeilNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lai Wen
Susanne Feil
Markus Wolters
Martin Thunemann
Frank Regler
Kjestine Schmidt
Andreas Friebe
Marcus Olbrich
Harald Langer
Meinrad Gawaz
Cor de Wit
Robert Feil
A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
description Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al. develop a cGMP sensor mouse to follow cGMP dynamics in platelets, and find that shear stress activates NO-cGMP-cGKI signaling during platelet aggregation to limit thrombosis.
format article
author Lai Wen
Susanne Feil
Markus Wolters
Martin Thunemann
Frank Regler
Kjestine Schmidt
Andreas Friebe
Marcus Olbrich
Harald Langer
Meinrad Gawaz
Cor de Wit
Robert Feil
author_facet Lai Wen
Susanne Feil
Markus Wolters
Martin Thunemann
Frank Regler
Kjestine Schmidt
Andreas Friebe
Marcus Olbrich
Harald Langer
Meinrad Gawaz
Cor de Wit
Robert Feil
author_sort Lai Wen
title A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
title_short A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
title_full A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
title_fullStr A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
title_full_unstemmed A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
title_sort shear-dependent no-cgmp-cgki cascade in platelets acts as an auto-regulatory brake of thrombosis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/bf3cc56a77f94f498614de8a9375ba7c
work_keys_str_mv AT laiwen asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT susannefeil asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT markuswolters asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT martinthunemann asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT frankregler asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT kjestineschmidt asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT andreasfriebe asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT marcusolbrich asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT haraldlanger asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT meinradgawaz asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT cordewit asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT robertfeil asheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT laiwen sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT susannefeil sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT markuswolters sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT martinthunemann sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT frankregler sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT kjestineschmidt sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT andreasfriebe sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT marcusolbrich sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT haraldlanger sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT meinradgawaz sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT cordewit sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
AT robertfeil sheardependentnocgmpcgkicascadeinplateletsactsasanautoregulatorybrakeofthrombosis
_version_ 1718383359866961920

Ejemplares similares