AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract. The levels of autoantibodies (AAbs) to double- and single-stranded DNA were studied in blood serum of sixty-one patients with hemorrhagic fever complicated by renal syndrome (HFRS), and twenty-five healthy persons using ELISA technique. In 95% of HFRS patients, the AAb levels to native (do...

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Autores principales:	D. G. Ishmukhametova, B. K. Temesgen, O. V. Vlasova, F. A. Babushkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoantibodies to double- and single-stranded dna elisa hemorrhagic fever complicated by renal syndrome Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bf3e20e15ff843acacf30e8e707de3f6
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spelling	oai:doaj.org-article:bf3e20e15ff843acacf30e8e707de3f62021-11-18T08:03:42ZAUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME1563-06252313-741X10.15789/1563-0625-2006-5-6-653-658https://doaj.org/article/bf3e20e15ff843acacf30e8e707de3f62014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/548https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The levels of autoantibodies (AAbs) to double- and single-stranded DNA were studied in blood serum of sixty-one patients with hemorrhagic fever complicated by renal syndrome (HFRS), and twenty-five healthy persons using ELISA technique. In 95% of HFRS patients, the AAb levels to native (double-stranded) DNA were close to their values in healthy group (resp., 0,02-0,26 vs 0,06-0,27 arbitrary units). The levels of AAbs to single-stranded level in serum of patients significantly exceeded the threshold values for healthy persons (resp., 0,37-0,80 vs 0,14-0,57 arbitrary units). The average levels of AAbs to single-stranded DNA in the patients were increased twice, in comparison with normal values. These results demonstrate that hantavirus infection followed by development of HFRS are accompanied by activation of autoimmune processes in the organism, being associated with increased synthesis of AAbs to denatured DNA. AAbs to denatured DNA autoantibodies may participate in inflammatory destruction of kidney glomerular capillaries in HFRS.D. G. IshmukhametovaB. K. TemesgenO. V. VlasovaF. A. BabushkinaSPb RAACIarticleautoantibodies to double- and single-stranded dnaelisahemorrhagic fever complicated by renal syndromeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 653-658 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibodies to double- and single-stranded dna elisa hemorrhagic fever complicated by renal syndrome Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibodies to double- and single-stranded dna elisa hemorrhagic fever complicated by renal syndrome Immunologic diseases. Allergy RC581-607 D. G. Ishmukhametova B. K. Temesgen O. V. Vlasova F. A. Babushkina AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
description	Abstract. The levels of autoantibodies (AAbs) to double- and single-stranded DNA were studied in blood serum of sixty-one patients with hemorrhagic fever complicated by renal syndrome (HFRS), and twenty-five healthy persons using ELISA technique. In 95% of HFRS patients, the AAb levels to native (double-stranded) DNA were close to their values in healthy group (resp., 0,02-0,26 vs 0,06-0,27 arbitrary units). The levels of AAbs to single-stranded level in serum of patients significantly exceeded the threshold values for healthy persons (resp., 0,37-0,80 vs 0,14-0,57 arbitrary units). The average levels of AAbs to single-stranded DNA in the patients were increased twice, in comparison with normal values. These results demonstrate that hantavirus infection followed by development of HFRS are accompanied by activation of autoimmune processes in the organism, being associated with increased synthesis of AAbs to denatured DNA. AAbs to denatured DNA autoantibodies may participate in inflammatory destruction of kidney glomerular capillaries in HFRS.
format	article
author	D. G. Ishmukhametova B. K. Temesgen O. V. Vlasova F. A. Babushkina
author_facet	D. G. Ishmukhametova B. K. Temesgen O. V. Vlasova F. A. Babushkina
author_sort	D. G. Ishmukhametova
title	AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_short	AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_full	AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_fullStr	AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_full_unstemmed	AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_sort	autoantibodies to dna in blood serum of patients with hemorrhagic fever with renal syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bf3e20e15ff843acacf30e8e707de3f6
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AUTOANTIBODIES TO DNA IN BLOOD SERUM OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

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