Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate

In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pa...

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Autores principales: Ryosuke Fujiwara, Shuhei Noda, Tsutomu Tanaka, Akihiko Kondo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bf3fa36764674195bc9355bdea02d0c9
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spelling oai:doaj.org-article:bf3fa36764674195bc9355bdea02d0c92021-12-02T14:40:42ZMetabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate10.1038/s41467-019-14024-12041-1723https://doaj.org/article/bf3fa36764674195bc9355bdea02d0c92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14024-1https://doaj.org/toc/2041-1723In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pathway derivatives.Ryosuke FujiwaraShuhei NodaTsutomu TanakaAkihiko KondoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ryosuke Fujiwara
Shuhei Noda
Tsutomu Tanaka
Akihiko Kondo
Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
description In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pathway derivatives.
format article
author Ryosuke Fujiwara
Shuhei Noda
Tsutomu Tanaka
Akihiko Kondo
author_facet Ryosuke Fujiwara
Shuhei Noda
Tsutomu Tanaka
Akihiko Kondo
author_sort Ryosuke Fujiwara
title Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_short Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_full Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_fullStr Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_full_unstemmed Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_sort metabolic engineering of escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/bf3fa36764674195bc9355bdea02d0c9
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AT tsutomutanaka metabolicengineeringofescherichiacoliforshikimatepathwayderivativeproductionfromglucosexylosecosubstrate
AT akihikokondo metabolicengineeringofescherichiacoliforshikimatepathwayderivativeproductionfromglucosexylosecosubstrate
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