Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate

In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pa...

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Main Authors:	Ryosuke Fujiwara, Shuhei Noda, Tsutomu Tanaka, Akihiko Kondo
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/bf3fa36764674195bc9355bdea02d0c9
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id	oai:doaj.org-article:bf3fa36764674195bc9355bdea02d0c9
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spelling	oai:doaj.org-article:bf3fa36764674195bc9355bdea02d0c92021-12-02T14:40:42ZMetabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate10.1038/s41467-019-14024-12041-1723https://doaj.org/article/bf3fa36764674195bc9355bdea02d0c92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14024-1https://doaj.org/toc/2041-1723In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pathway derivatives.Ryosuke FujiwaraShuhei NodaTsutomu TanakaAkihiko KondoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryosuke Fujiwara Shuhei Noda Tsutomu Tanaka Akihiko Kondo Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
description	In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pathway derivatives.
format	article
author	Ryosuke Fujiwara Shuhei Noda Tsutomu Tanaka Akihiko Kondo
author_facet	Ryosuke Fujiwara Shuhei Noda Tsutomu Tanaka Akihiko Kondo
author_sort	Ryosuke Fujiwara
title	Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_short	Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_full	Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_fullStr	Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_full_unstemmed	Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
title_sort	metabolic engineering of escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bf3fa36764674195bc9355bdea02d0c9
work_keys_str_mv	AT ryosukefujiwara metabolicengineeringofescherichiacoliforshikimatepathwayderivativeproductionfromglucosexylosecosubstrate AT shuheinoda metabolicengineeringofescherichiacoliforshikimatepathwayderivativeproductionfromglucosexylosecosubstrate AT tsutomutanaka metabolicengineeringofescherichiacoliforshikimatepathwayderivativeproductionfromglucosexylosecosubstrate AT akihikokondo metabolicengineeringofescherichiacoliforshikimatepathwayderivativeproductionfromglucosexylosecosubstrate
_version_	1718390194876448768

Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate

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