Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.

A key question in the analysis of hippocampal memory relates to how attention modulates the encoding and long-term retrieval of spatial and nonspatial representations in this region. To address this question, we recorded from single cells over a period of 5 days in the CA1 region of the dorsal hippo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Isabel A Muzzio, Liat Levita, Jayant Kulkarni, Joseph Monaco, Clifford Kentros, Matthew Stead, Larry F Abbott, Eric R Kandel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bf4243c096be4c6cbbc9e6e76ed26e83
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf4243c096be4c6cbbc9e6e76ed26e83
record_format	dspace
spelling	oai:doaj.org-article:bf4243c096be4c6cbbc9e6e76ed26e832021-11-25T05:34:07ZAttention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.1544-91731545-788510.1371/journal.pbio.1000140https://doaj.org/article/bf4243c096be4c6cbbc9e6e76ed26e832009-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19564903/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885A key question in the analysis of hippocampal memory relates to how attention modulates the encoding and long-term retrieval of spatial and nonspatial representations in this region. To address this question, we recorded from single cells over a period of 5 days in the CA1 region of the dorsal hippocampus while mice acquired one of two goal-oriented tasks. These tasks required the animals to find a hidden food reward by attending to either the visuospatial environment or a particular odor presented in shifting spatial locations. Attention to the visuospatial environment increased the stability of visuospatial representations and phase locking to gamma oscillations--a form of neuronal synchronization thought to underlie the attentional mechanism necessary for processing task-relevant information. Attention to a spatially shifting olfactory cue compromised the stability of place fields and increased the stability of reward-associated odor representations, which were most consistently retrieved during periods of sniffing and digging when animals were restricted to the cup locations. Together, these results suggest that attention selectively modulates the encoding and retrieval of hippocampal representations by enhancing physiological responses to task-relevant information.Isabel A MuzzioLiat LevitaJayant KulkarniJoseph MonacoClifford KentrosMatthew SteadLarry F AbbottEric R KandelPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 6, p e1000140 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Isabel A Muzzio Liat Levita Jayant Kulkarni Joseph Monaco Clifford Kentros Matthew Stead Larry F Abbott Eric R Kandel Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
description	A key question in the analysis of hippocampal memory relates to how attention modulates the encoding and long-term retrieval of spatial and nonspatial representations in this region. To address this question, we recorded from single cells over a period of 5 days in the CA1 region of the dorsal hippocampus while mice acquired one of two goal-oriented tasks. These tasks required the animals to find a hidden food reward by attending to either the visuospatial environment or a particular odor presented in shifting spatial locations. Attention to the visuospatial environment increased the stability of visuospatial representations and phase locking to gamma oscillations--a form of neuronal synchronization thought to underlie the attentional mechanism necessary for processing task-relevant information. Attention to a spatially shifting olfactory cue compromised the stability of place fields and increased the stability of reward-associated odor representations, which were most consistently retrieved during periods of sniffing and digging when animals were restricted to the cup locations. Together, these results suggest that attention selectively modulates the encoding and retrieval of hippocampal representations by enhancing physiological responses to task-relevant information.
format	article
author	Isabel A Muzzio Liat Levita Jayant Kulkarni Joseph Monaco Clifford Kentros Matthew Stead Larry F Abbott Eric R Kandel
author_facet	Isabel A Muzzio Liat Levita Jayant Kulkarni Joseph Monaco Clifford Kentros Matthew Stead Larry F Abbott Eric R Kandel
author_sort	Isabel A Muzzio
title	Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
title_short	Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
title_full	Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
title_fullStr	Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
title_full_unstemmed	Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
title_sort	attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/bf4243c096be4c6cbbc9e6e76ed26e83
work_keys_str_mv	AT isabelamuzzio attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT liatlevita attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT jayantkulkarni attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT josephmonaco attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT cliffordkentros attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT matthewstead attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT larryfabbott attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus AT ericrkandel attentionenhancestheretrievalandstabilityofvisuospatialandolfactoryrepresentationsinthedorsalhippocampus
_version_	1718414600725069824

Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.

Ejemplares similares