A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

In prostate cancer, chromatin structure can impact the transcriptome. Here, the authors develop high resolution chromatin interaction maps in prostate cancer cells using in situ Hi-C, revealing prostate cancer-specific TADs and enhancer-promoter loops surrounding the androgen receptor (AR) locus.

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Autores principales:	Suhn Kyong Rhie, Andrew A. Perez, Fides D. Lay, Shannon Schreiner, Jiani Shi, Jenevieve Polin, Peggy J. Farnham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf4333a7da084e70ab3ac3f87cbcc657
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spelling	oai:doaj.org-article:bf4333a7da084e70ab3ac3f87cbcc6572021-12-02T14:35:31ZA high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome10.1038/s41467-019-12079-82041-1723https://doaj.org/article/bf4333a7da084e70ab3ac3f87cbcc6572019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12079-8https://doaj.org/toc/2041-1723In prostate cancer, chromatin structure can impact the transcriptome. Here, the authors develop high resolution chromatin interaction maps in prostate cancer cells using in situ Hi-C, revealing prostate cancer-specific TADs and enhancer-promoter loops surrounding the androgen receptor (AR) locus.Suhn Kyong RhieAndrew A. PerezFides D. LayShannon SchreinerJiani ShiJenevieve PolinPeggy J. FarnhamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Suhn Kyong Rhie Andrew A. Perez Fides D. Lay Shannon Schreiner Jiani Shi Jenevieve Polin Peggy J. Farnham A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome
description	In prostate cancer, chromatin structure can impact the transcriptome. Here, the authors develop high resolution chromatin interaction maps in prostate cancer cells using in situ Hi-C, revealing prostate cancer-specific TADs and enhancer-promoter loops surrounding the androgen receptor (AR) locus.
format	article
author	Suhn Kyong Rhie Andrew A. Perez Fides D. Lay Shannon Schreiner Jiani Shi Jenevieve Polin Peggy J. Farnham
author_facet	Suhn Kyong Rhie Andrew A. Perez Fides D. Lay Shannon Schreiner Jiani Shi Jenevieve Polin Peggy J. Farnham
author_sort	Suhn Kyong Rhie
title	A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome
title_short	A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome
title_full	A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome
title_fullStr	A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome
title_full_unstemmed	A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome
title_sort	high-resolution 3d epigenomic map reveals insights into the creation of the prostate cancer transcriptome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bf4333a7da084e70ab3ac3f87cbcc657
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A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

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