Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation

The segregation of distinct cell populations to form sharp boundaries is crucial for stabilising tissue organisation, for example during hindbrain segmentation in craniofacial development. Two types of mechanisms have been found to underlie cell segregation: differential adhesion mediated by cadheri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	David G. Wilkinson
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Eph receptor ephrin cadherin cell segregation boundary formation hindbrain segmentation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bf434c005e314e90971b6fbe98a8aa2f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf434c005e314e90971b6fbe98a8aa2f
record_format	dspace
spelling	oai:doaj.org-article:bf434c005e314e90971b6fbe98a8aa2f2021-11-12T16:44:42ZInterplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation2296-634X10.3389/fcell.2021.784039https://doaj.org/article/bf434c005e314e90971b6fbe98a8aa2f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.784039/fullhttps://doaj.org/toc/2296-634XThe segregation of distinct cell populations to form sharp boundaries is crucial for stabilising tissue organisation, for example during hindbrain segmentation in craniofacial development. Two types of mechanisms have been found to underlie cell segregation: differential adhesion mediated by cadherins, and Eph receptor and ephrin signalling at the heterotypic interface which regulates cell adhesion, cortical tension and repulsion. An interplay occurs between these mechanisms since cadherins have been found to contribute to Eph-ephrin-mediated cell segregation. This may reflect that Eph receptor activation acts through multiple pathways to decrease cadherin-mediated adhesion which can drive cell segregation. However, Eph receptors mainly drive cell segregation through increased heterotypic tension or repulsion. Cadherins contribute to cell segregation by antagonising homotypic tension within each cell population. This suppression of homotypic tension increases the difference with heterotypic tension triggered by Eph receptor activation, and it is this differential tension that drives cell segregation and border sharpening.David G. WilkinsonFrontiers Media S.A.articleEph receptorephrincadherincell segregationboundary formationhindbrain segmentationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Eph receptor ephrin cadherin cell segregation boundary formation hindbrain segmentation Biology (General) QH301-705.5
spellingShingle	Eph receptor ephrin cadherin cell segregation boundary formation hindbrain segmentation Biology (General) QH301-705.5 David G. Wilkinson Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
description	The segregation of distinct cell populations to form sharp boundaries is crucial for stabilising tissue organisation, for example during hindbrain segmentation in craniofacial development. Two types of mechanisms have been found to underlie cell segregation: differential adhesion mediated by cadherins, and Eph receptor and ephrin signalling at the heterotypic interface which regulates cell adhesion, cortical tension and repulsion. An interplay occurs between these mechanisms since cadherins have been found to contribute to Eph-ephrin-mediated cell segregation. This may reflect that Eph receptor activation acts through multiple pathways to decrease cadherin-mediated adhesion which can drive cell segregation. However, Eph receptors mainly drive cell segregation through increased heterotypic tension or repulsion. Cadherins contribute to cell segregation by antagonising homotypic tension within each cell population. This suppression of homotypic tension increases the difference with heterotypic tension triggered by Eph receptor activation, and it is this differential tension that drives cell segregation and border sharpening.
format	article
author	David G. Wilkinson
author_facet	David G. Wilkinson
author_sort	David G. Wilkinson
title	Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
title_short	Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
title_full	Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
title_fullStr	Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
title_full_unstemmed	Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
title_sort	interplay of eph-ephrin signalling and cadherin function in cell segregation and boundary formation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bf434c005e314e90971b6fbe98a8aa2f
work_keys_str_mv	AT davidgwilkinson interplayofephephrinsignallingandcadherinfunctionincellsegregationandboundaryformation
_version_	1718430394216349696

Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation

Ejemplares similares