Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation

The characterisation of B cell progenitors could benefit from single cell RNA analysis. Here the authors show distinct transcriptional profiles of B cell progenitors which are dependent upon pre-BCR and these profiles can be related to B cell transformation in lymphoblastic leukaemia.

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Autores principales:	Robin D. Lee, Sarah A. Munro, Todd P. Knutson, Rebecca S. LaRue, Lynn M. Heltemes-Harris, Michael A. Farrar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf459a4d617646fcb5ab701582999f27
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spelling	oai:doaj.org-article:bf459a4d617646fcb5ab701582999f272021-11-28T12:35:30ZSingle-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation10.1038/s41467-021-27232-52041-1723https://doaj.org/article/bf459a4d617646fcb5ab701582999f272021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27232-5https://doaj.org/toc/2041-1723The characterisation of B cell progenitors could benefit from single cell RNA analysis. Here the authors show distinct transcriptional profiles of B cell progenitors which are dependent upon pre-BCR and these profiles can be related to B cell transformation in lymphoblastic leukaemia.Robin D. LeeSarah A. MunroTodd P. KnutsonRebecca S. LaRueLynn M. Heltemes-HarrisMichael A. FarrarNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robin D. Lee Sarah A. Munro Todd P. Knutson Rebecca S. LaRue Lynn M. Heltemes-Harris Michael A. Farrar Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
description	The characterisation of B cell progenitors could benefit from single cell RNA analysis. Here the authors show distinct transcriptional profiles of B cell progenitors which are dependent upon pre-BCR and these profiles can be related to B cell transformation in lymphoblastic leukaemia.
format	article
author	Robin D. Lee Sarah A. Munro Todd P. Knutson Rebecca S. LaRue Lynn M. Heltemes-Harris Michael A. Farrar
author_facet	Robin D. Lee Sarah A. Munro Todd P. Knutson Rebecca S. LaRue Lynn M. Heltemes-Harris Michael A. Farrar
author_sort	Robin D. Lee
title	Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
title_short	Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
title_full	Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
title_fullStr	Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
title_full_unstemmed	Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
title_sort	single-cell analysis identifies dynamic gene expression networks that govern b cell development and transformation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf459a4d617646fcb5ab701582999f27
work_keys_str_mv	AT robindlee singlecellanalysisidentifiesdynamicgeneexpressionnetworksthatgovernbcelldevelopmentandtransformation AT sarahamunro singlecellanalysisidentifiesdynamicgeneexpressionnetworksthatgovernbcelldevelopmentandtransformation AT toddpknutson singlecellanalysisidentifiesdynamicgeneexpressionnetworksthatgovernbcelldevelopmentandtransformation AT rebeccaslarue singlecellanalysisidentifiesdynamicgeneexpressionnetworksthatgovernbcelldevelopmentandtransformation AT lynnmheltemesharris singlecellanalysisidentifiesdynamicgeneexpressionnetworksthatgovernbcelldevelopmentandtransformation AT michaelafarrar singlecellanalysisidentifiesdynamicgeneexpressionnetworksthatgovernbcelldevelopmentandtransformation
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Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation

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