Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center

Inflammatory bowel disease (IBD) is a risk factor for C. difficile infection (CDI), which, in turn, complicates the clinical course of IBD. Fecal microbiota transplantation (FMT) is safe and effective in patients with IBD and recurrent CDI (rCDI). In our study, patients with IBD and rCDI received FM...

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Autores principales:	Gianluca Ianiro, Stefano Bibbò, Serena Porcari, Carlo Romano Settanni, Federica Giambò, Andreea Roxana Curta, Gianluca Quaranta, Franco Scaldaferri, Luca Masucci, Maurizio Sanguinetti, Antonio Gasbarrini, Giovanni Cammarota
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	fecal microbiota transplantation clostridioides difficile infection inflammatory bowel disease gut microbiota microbiome ulcerative colitis crohn’s disease Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/bf45d0bd79d740989cc44640b8589b8b
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spelling	oai:doaj.org-article:bf45d0bd79d740989cc44640b8589b8b2021-11-04T15:00:42ZFecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center1949-09761949-098410.1080/19490976.2021.1994834https://doaj.org/article/bf45d0bd79d740989cc44640b8589b8b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1994834https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Inflammatory bowel disease (IBD) is a risk factor for C. difficile infection (CDI), which, in turn, complicates the clinical course of IBD. Fecal microbiota transplantation (FMT) is safe and effective in patients with IBD and recurrent CDI (rCDI). In our study, patients with IBD and rCDI received FMT by colonoscopy and were followed-up for 8 weeks. The primary outcome was negative C. difficile toxin 8 weeks after FMT. Eighteen patients with IBD were enrolled. Eight patients received sequential FMT either for pseudomembranous colitis or failure of single fecal infusion. At 8-week follow-up the C. difficile toxin was negative in 17 patients, and most (83%) experienced also improvement of IBD disease activity. Overall, we did not observe any serious adverse event. FMT appears to be highly effective and safe in patients with IBD and rCDI and is likely not only to eradicate CDI but also to improve disease activity of IBD.Gianluca IaniroStefano BibbòSerena PorcariCarlo Romano SettanniFederica GiambòAndreea Roxana CurtaGianluca QuarantaFranco ScaldaferriLuca MasucciMaurizio SanguinettiAntonio GasbarriniGiovanni CammarotaTaylor & Francis Grouparticlefecal microbiota transplantationclostridioides difficile infectioninflammatory bowel diseasegut microbiotamicrobiomeulcerative colitiscrohn’s diseaseDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fecal microbiota transplantation clostridioides difficile infection inflammatory bowel disease gut microbiota microbiome ulcerative colitis crohn’s disease Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	fecal microbiota transplantation clostridioides difficile infection inflammatory bowel disease gut microbiota microbiome ulcerative colitis crohn’s disease Diseases of the digestive system. Gastroenterology RC799-869 Gianluca Ianiro Stefano Bibbò Serena Porcari Carlo Romano Settanni Federica Giambò Andreea Roxana Curta Gianluca Quaranta Franco Scaldaferri Luca Masucci Maurizio Sanguinetti Antonio Gasbarrini Giovanni Cammarota Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center
description	Inflammatory bowel disease (IBD) is a risk factor for C. difficile infection (CDI), which, in turn, complicates the clinical course of IBD. Fecal microbiota transplantation (FMT) is safe and effective in patients with IBD and recurrent CDI (rCDI). In our study, patients with IBD and rCDI received FMT by colonoscopy and were followed-up for 8 weeks. The primary outcome was negative C. difficile toxin 8 weeks after FMT. Eighteen patients with IBD were enrolled. Eight patients received sequential FMT either for pseudomembranous colitis or failure of single fecal infusion. At 8-week follow-up the C. difficile toxin was negative in 17 patients, and most (83%) experienced also improvement of IBD disease activity. Overall, we did not observe any serious adverse event. FMT appears to be highly effective and safe in patients with IBD and rCDI and is likely not only to eradicate CDI but also to improve disease activity of IBD.
format	article
author	Gianluca Ianiro Stefano Bibbò Serena Porcari Carlo Romano Settanni Federica Giambò Andreea Roxana Curta Gianluca Quaranta Franco Scaldaferri Luca Masucci Maurizio Sanguinetti Antonio Gasbarrini Giovanni Cammarota
author_facet	Gianluca Ianiro Stefano Bibbò Serena Porcari Carlo Romano Settanni Federica Giambò Andreea Roxana Curta Gianluca Quaranta Franco Scaldaferri Luca Masucci Maurizio Sanguinetti Antonio Gasbarrini Giovanni Cammarota
author_sort	Gianluca Ianiro
title	Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center
title_short	Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center
title_full	Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center
title_fullStr	Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center
title_full_unstemmed	Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center
title_sort	fecal microbiota transplantation for recurrent c. difficile infection in patients with inflammatory bowel disease: experience of a large-volume european fmt center
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/bf45d0bd79d740989cc44640b8589b8b
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Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center

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