Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry

Abstract Mass spectrometry coupled to low-temperature plasma ionization (LTPI) allows for immediate and easy analysis of compounds from the surface of a sample at ambient conditions. The efficiency of this process, however, strongly depends on the successful desorption of the analyte from the surfac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andreas Kiontke, Mehrzad Roudini, Susan Billig, Amarghan Fakhfouri, Andreas Winkler, Claudia Birkemeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf478610e79f4216a23b289a2b70b713
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf478610e79f4216a23b289a2b70b713
record_format	dspace
spelling	oai:doaj.org-article:bf478610e79f4216a23b289a2b70b7132021-12-02T14:06:50ZSurface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry10.1038/s41598-021-82423-w2045-2322https://doaj.org/article/bf478610e79f4216a23b289a2b70b7132021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82423-whttps://doaj.org/toc/2045-2322Abstract Mass spectrometry coupled to low-temperature plasma ionization (LTPI) allows for immediate and easy analysis of compounds from the surface of a sample at ambient conditions. The efficiency of this process, however, strongly depends on the successful desorption of the analyte from the surface to the gas phase. Whilst conventional sample heating can improve analyte desorption, heating is not desirable with respect to the stability of thermally labile analytes. In this study using aromatic amines as model compounds, we demonstrate that (1) surface acoustic wave nebulization (SAWN) can significantly improve compound desorption for LTPI without heating the sample. Furthermore, (2) SAWN-assisted LTPI shows a response enhancement up to a factor of 8 for polar compounds such as aminophenols and phenylenediamines suggesting a paradigm shift in the ionization mechanism. Additional assets of the new technique demonstrated here are (3) a reduced analyte selectivity (the interquartile range of the response decreased by a factor of 7)—a significant benefit in non-targeted analysis of complex samples—and (4) the possibility for automated online monitoring using an autosampler. Finally, (5) the small size of the microfluidic SAWN-chip enables the implementation of the method into miniaturized, mobile LTPI probes.Andreas KiontkeMehrzad RoudiniSusan BilligAmarghan FakhfouriAndreas WinklerClaudia BirkemeyerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andreas Kiontke Mehrzad Roudini Susan Billig Amarghan Fakhfouri Andreas Winkler Claudia Birkemeyer Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
description	Abstract Mass spectrometry coupled to low-temperature plasma ionization (LTPI) allows for immediate and easy analysis of compounds from the surface of a sample at ambient conditions. The efficiency of this process, however, strongly depends on the successful desorption of the analyte from the surface to the gas phase. Whilst conventional sample heating can improve analyte desorption, heating is not desirable with respect to the stability of thermally labile analytes. In this study using aromatic amines as model compounds, we demonstrate that (1) surface acoustic wave nebulization (SAWN) can significantly improve compound desorption for LTPI without heating the sample. Furthermore, (2) SAWN-assisted LTPI shows a response enhancement up to a factor of 8 for polar compounds such as aminophenols and phenylenediamines suggesting a paradigm shift in the ionization mechanism. Additional assets of the new technique demonstrated here are (3) a reduced analyte selectivity (the interquartile range of the response decreased by a factor of 7)—a significant benefit in non-targeted analysis of complex samples—and (4) the possibility for automated online monitoring using an autosampler. Finally, (5) the small size of the microfluidic SAWN-chip enables the implementation of the method into miniaturized, mobile LTPI probes.
format	article
author	Andreas Kiontke Mehrzad Roudini Susan Billig Amarghan Fakhfouri Andreas Winkler Claudia Birkemeyer
author_facet	Andreas Kiontke Mehrzad Roudini Susan Billig Amarghan Fakhfouri Andreas Winkler Claudia Birkemeyer
author_sort	Andreas Kiontke
title	Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
title_short	Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
title_full	Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
title_fullStr	Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
title_full_unstemmed	Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
title_sort	surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf478610e79f4216a23b289a2b70b713
work_keys_str_mv	AT andreaskiontke surfaceacousticwavenebulizationimprovescompoundselectivityoflowtemperatureplasmaionizationformassspectrometry AT mehrzadroudini surfaceacousticwavenebulizationimprovescompoundselectivityoflowtemperatureplasmaionizationformassspectrometry AT susanbillig surfaceacousticwavenebulizationimprovescompoundselectivityoflowtemperatureplasmaionizationformassspectrometry AT amarghanfakhfouri surfaceacousticwavenebulizationimprovescompoundselectivityoflowtemperatureplasmaionizationformassspectrometry AT andreaswinkler surfaceacousticwavenebulizationimprovescompoundselectivityoflowtemperatureplasmaionizationformassspectrometry AT claudiabirkemeyer surfaceacousticwavenebulizationimprovescompoundselectivityoflowtemperatureplasmaionizationformassspectrometry
_version_	1718391987647807488

Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry

Ejemplares similares