Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation
Environmental exposures represent a significant health hazard, which cumulatively may be responsible for up to 2/3 of all chronic non-communicable disease and associated mortality (Global Burden of Disease Study and The Lancet Commission on Pollution and Health), which has given rise to a new concep...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bf47ce30b4974e83b327377e2cb459d3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bf47ce30b4974e83b327377e2cb459d3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bf47ce30b4974e83b327377e2cb459d32021-11-18T09:43:52ZRedox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation2296-889X10.3389/fmolb.2021.784910https://doaj.org/article/bf47ce30b4974e83b327377e2cb459d32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.784910/fullhttps://doaj.org/toc/2296-889XEnvironmental exposures represent a significant health hazard, which cumulatively may be responsible for up to 2/3 of all chronic non-communicable disease and associated mortality (Global Burden of Disease Study and The Lancet Commission on Pollution and Health), which has given rise to a new concept of the exposome: the sum of environmental factors in every individual’s experience. Noise is part of the exposome and is increasingly being investigated as a health risk factor impacting neurological, cardiometabolic, endocrine, and immune health. Beyond the well-characterized effects of high-intensity noise on cochlear damage, noise is relatively well-studied in the cardiovascular field, where evidence is emerging from both human and translational experiments that noise from traffic-related sources could represent a risk factor for hypertension, ischemic heart disease, diabetes, and atherosclerosis. In the present review, we comprehensively discuss the current state of knowledge in the field of noise research. We give a brief survey of the literature documenting experiments in noise exposure in both humans and animals with a focus on cardiovascular disease. We also discuss the mechanisms that have been uncovered in recent years that describe how exposure to noise affects physiological homeostasis, leading to aberrant redox signaling resulting in metabolic and immune consequences, both of which have considerable impact on cardiovascular health. Additionally, we discuss the molecular pathways of redox involvement in the stress responses to noise and how they manifest in disruptions of the circadian rhythm, inflammatory signaling, gut microbiome composition, epigenetic landscape and vessel function.Katie FrenisKatie FrenisMarin KunticOmar HahadOmar HahadMaria Teresa Bayo JimenezMatthias OelzeSteffen DaubSebastian StevenThomas MünzelThomas MünzelAndreas DaiberAndreas DaiberFrontiers Media S.A.articlesources of reactive oxygen speciesredox switchesoxidative stresscardiovascular diseaseneuronal complicationstraffic noise exposureBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
sources of reactive oxygen species redox switches oxidative stress cardiovascular disease neuronal complications traffic noise exposure Biology (General) QH301-705.5 |
| spellingShingle |
sources of reactive oxygen species redox switches oxidative stress cardiovascular disease neuronal complications traffic noise exposure Biology (General) QH301-705.5 Katie Frenis Katie Frenis Marin Kuntic Omar Hahad Omar Hahad Maria Teresa Bayo Jimenez Matthias Oelze Steffen Daub Sebastian Steven Thomas Münzel Thomas Münzel Andreas Daiber Andreas Daiber Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation |
| description |
Environmental exposures represent a significant health hazard, which cumulatively may be responsible for up to 2/3 of all chronic non-communicable disease and associated mortality (Global Burden of Disease Study and The Lancet Commission on Pollution and Health), which has given rise to a new concept of the exposome: the sum of environmental factors in every individual’s experience. Noise is part of the exposome and is increasingly being investigated as a health risk factor impacting neurological, cardiometabolic, endocrine, and immune health. Beyond the well-characterized effects of high-intensity noise on cochlear damage, noise is relatively well-studied in the cardiovascular field, where evidence is emerging from both human and translational experiments that noise from traffic-related sources could represent a risk factor for hypertension, ischemic heart disease, diabetes, and atherosclerosis. In the present review, we comprehensively discuss the current state of knowledge in the field of noise research. We give a brief survey of the literature documenting experiments in noise exposure in both humans and animals with a focus on cardiovascular disease. We also discuss the mechanisms that have been uncovered in recent years that describe how exposure to noise affects physiological homeostasis, leading to aberrant redox signaling resulting in metabolic and immune consequences, both of which have considerable impact on cardiovascular health. Additionally, we discuss the molecular pathways of redox involvement in the stress responses to noise and how they manifest in disruptions of the circadian rhythm, inflammatory signaling, gut microbiome composition, epigenetic landscape and vessel function. |
| format |
article |
| author |
Katie Frenis Katie Frenis Marin Kuntic Omar Hahad Omar Hahad Maria Teresa Bayo Jimenez Matthias Oelze Steffen Daub Sebastian Steven Thomas Münzel Thomas Münzel Andreas Daiber Andreas Daiber |
| author_facet |
Katie Frenis Katie Frenis Marin Kuntic Omar Hahad Omar Hahad Maria Teresa Bayo Jimenez Matthias Oelze Steffen Daub Sebastian Steven Thomas Münzel Thomas Münzel Andreas Daiber Andreas Daiber |
| author_sort |
Katie Frenis |
| title |
Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation |
| title_short |
Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation |
| title_full |
Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation |
| title_fullStr |
Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation |
| title_full_unstemmed |
Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation |
| title_sort |
redox switches in noise-induced cardiovascular and neuronal dysregulation |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/bf47ce30b4974e83b327377e2cb459d3 |
| work_keys_str_mv |
AT katiefrenis redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT katiefrenis redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT marinkuntic redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT omarhahad redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT omarhahad redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT mariateresabayojimenez redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT matthiasoelze redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT steffendaub redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT sebastiansteven redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT thomasmunzel redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT thomasmunzel redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT andreasdaiber redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation AT andreasdaiber redoxswitchesinnoiseinducedcardiovascularandneuronaldysregulation |
| _version_ |
1718420926269227008 |