Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.

Despite a long history of investigation, many bacteria associated with the human oral cavity have yet to be cultured. Studies that correlate the presence or abundance of uncultured species with oral health or disease highlight the importance of these community members. Thus, we sequenced several sin...

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Autores principales:	Alisha G Campbell, James H Campbell, Patrick Schwientek, Tanja Woyke, Alexander Sczyrba, Steve Allman, Clifford J Beall, Ann Griffen, Eugene Leys, Mircea Podar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf4c8287bd8d4b68ab9920217bf18816
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spelling	oai:doaj.org-article:bf4c8287bd8d4b68ab9920217bf188162021-11-18T07:52:02ZMultiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.1932-620310.1371/journal.pone.0059361https://doaj.org/article/bf4c8287bd8d4b68ab9920217bf188162013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555659/?tool=EBIhttps://doaj.org/toc/1932-6203Despite a long history of investigation, many bacteria associated with the human oral cavity have yet to be cultured. Studies that correlate the presence or abundance of uncultured species with oral health or disease highlight the importance of these community members. Thus, we sequenced several single-cell genomic amplicons from Desulfobulbus and Desulfovibrio (class Deltaproteobacteria) to better understand their function within the human oral community and their association with periodontitis, as well as other systemic diseases. Genomic data from oral Desulfobulbus and Desulfovibrio species were compared to other available deltaproteobacterial genomes, including from a subset of host-associated species. While both groups share a large number of genes with other environmental Deltaproteobacteria genomes, they encode a wide array of unique genes that appear to function in survival in a host environment. Many of these genes are similar to virulence and host adaptation factors of known human pathogens, suggesting that the oral Deltaproteobacteria have the potential to play a role in the etiology of periodontal disease.Alisha G CampbellJames H CampbellPatrick SchwientekTanja WoykeAlexander SczyrbaSteve AllmanClifford J BeallAnn GriffenEugene LeysMircea PodarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59361 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alisha G Campbell James H Campbell Patrick Schwientek Tanja Woyke Alexander Sczyrba Steve Allman Clifford J Beall Ann Griffen Eugene Leys Mircea Podar Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
description	Despite a long history of investigation, many bacteria associated with the human oral cavity have yet to be cultured. Studies that correlate the presence or abundance of uncultured species with oral health or disease highlight the importance of these community members. Thus, we sequenced several single-cell genomic amplicons from Desulfobulbus and Desulfovibrio (class Deltaproteobacteria) to better understand their function within the human oral community and their association with periodontitis, as well as other systemic diseases. Genomic data from oral Desulfobulbus and Desulfovibrio species were compared to other available deltaproteobacterial genomes, including from a subset of host-associated species. While both groups share a large number of genes with other environmental Deltaproteobacteria genomes, they encode a wide array of unique genes that appear to function in survival in a host environment. Many of these genes are similar to virulence and host adaptation factors of known human pathogens, suggesting that the oral Deltaproteobacteria have the potential to play a role in the etiology of periodontal disease.
format	article
author	Alisha G Campbell James H Campbell Patrick Schwientek Tanja Woyke Alexander Sczyrba Steve Allman Clifford J Beall Ann Griffen Eugene Leys Mircea Podar
author_facet	Alisha G Campbell James H Campbell Patrick Schwientek Tanja Woyke Alexander Sczyrba Steve Allman Clifford J Beall Ann Griffen Eugene Leys Mircea Podar
author_sort	Alisha G Campbell
title	Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
title_short	Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
title_full	Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
title_fullStr	Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
title_full_unstemmed	Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
title_sort	multiple single-cell genomes provide insight into functions of uncultured deltaproteobacteria in the human oral cavity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bf4c8287bd8d4b68ab9920217bf18816
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Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.

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