Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
Cellular heterogeneity can confound functional genomics analyses of bulk tissues. Here, Donovan et al. deconvolute bulk GTEx RNA-seq data utilizing scRNA-seq data from the Tabula Muris project and show the power of using cell populations in eQTL analyses to identify disease and cell-type-associated...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/bf4f52ec9de84c23838bce86931d7b44 |
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| Sumario: | Cellular heterogeneity can confound functional genomics analyses of bulk tissues. Here, Donovan et al. deconvolute bulk GTEx RNA-seq data utilizing scRNA-seq data from the Tabula Muris project and show the power of using cell populations in eQTL analyses to identify disease and cell-type-associated regulatory variants. |
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