Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants

Cellular heterogeneity can confound functional genomics analyses of bulk tissues. Here, Donovan et al. deconvolute bulk GTEx RNA-seq data utilizing scRNA-seq data from the Tabula Muris project and show the power of using cell populations in eQTL analyses to identify disease and cell-type-associated...

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Autores principales:	Margaret K. R. Donovan, Agnieszka D’Antonio-Chronowska, Matteo D’Antonio, Kelly A. Frazer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf4f52ec9de84c23838bce86931d7b44
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spelling	oai:doaj.org-article:bf4f52ec9de84c23838bce86931d7b442021-12-02T17:31:39ZCellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants10.1038/s41467-020-14561-02041-1723https://doaj.org/article/bf4f52ec9de84c23838bce86931d7b442020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14561-0https://doaj.org/toc/2041-1723Cellular heterogeneity can confound functional genomics analyses of bulk tissues. Here, Donovan et al. deconvolute bulk GTEx RNA-seq data utilizing scRNA-seq data from the Tabula Muris project and show the power of using cell populations in eQTL analyses to identify disease and cell-type-associated regulatory variants.Margaret K. R. DonovanAgnieszka D’Antonio-ChronowskaMatteo D’AntonioKelly A. FrazerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Margaret K. R. Donovan Agnieszka D’Antonio-Chronowska Matteo D’Antonio Kelly A. Frazer Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
description	Cellular heterogeneity can confound functional genomics analyses of bulk tissues. Here, Donovan et al. deconvolute bulk GTEx RNA-seq data utilizing scRNA-seq data from the Tabula Muris project and show the power of using cell populations in eQTL analyses to identify disease and cell-type-associated regulatory variants.
format	article
author	Margaret K. R. Donovan Agnieszka D’Antonio-Chronowska Matteo D’Antonio Kelly A. Frazer
author_facet	Margaret K. R. Donovan Agnieszka D’Antonio-Chronowska Matteo D’Antonio Kelly A. Frazer
author_sort	Margaret K. R. Donovan
title	Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
title_short	Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
title_full	Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
title_fullStr	Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
title_full_unstemmed	Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants
title_sort	cellular deconvolution of gtex tissues powers discovery of disease and cell-type associated regulatory variants
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bf4f52ec9de84c23838bce86931d7b44
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Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants

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