EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas.

EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas.

Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification. As an initial step toward screening patients for cancer...

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Autores principales: Russell J H Ryan, Mai Nitta, Darrell Borger, Lawrence R Zukerberg, Judith A Ferry, Nancy Lee Harris, A John Iafrate, Bradley E Bernstein, Aliyah R Sohani, Long Phi Le
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/bf516049533c48d780c32bc7b0f7af86
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