Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation

Abscopal responses in patients and preclinical models following radiation therapy are rare. Here the authors show that, in murine tumor models, reducing adrenergic stress or β2-adrenergic receptor signalling not only improves control of the irradiated tumor but significantly increases abscopal event...

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Autores principales:	Minhui Chen, Guanxi Qiao, Bonnie L. Hylander, Hemn Mohammadpour, Xiang-Yang Wang, John R. Subjeck, Anurag K. Singh, Elizabeth A. Repasky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf540c3fc9a8411c9f4089714a3b4c2c
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spelling	oai:doaj.org-article:bf540c3fc9a8411c9f4089714a3b4c2c2021-12-02T14:40:42ZAdrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation10.1038/s41467-020-15676-02041-1723https://doaj.org/article/bf540c3fc9a8411c9f4089714a3b4c2c2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15676-0https://doaj.org/toc/2041-1723Abscopal responses in patients and preclinical models following radiation therapy are rare. Here the authors show that, in murine tumor models, reducing adrenergic stress or β2-adrenergic receptor signalling not only improves control of the irradiated tumor but significantly increases abscopal events.Minhui ChenGuanxi QiaoBonnie L. HylanderHemn MohammadpourXiang-Yang WangJohn R. SubjeckAnurag K. SinghElizabeth A. RepaskyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minhui Chen Guanxi Qiao Bonnie L. Hylander Hemn Mohammadpour Xiang-Yang Wang John R. Subjeck Anurag K. Singh Elizabeth A. Repasky Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
description	Abscopal responses in patients and preclinical models following radiation therapy are rare. Here the authors show that, in murine tumor models, reducing adrenergic stress or β2-adrenergic receptor signalling not only improves control of the irradiated tumor but significantly increases abscopal events.
format	article
author	Minhui Chen Guanxi Qiao Bonnie L. Hylander Hemn Mohammadpour Xiang-Yang Wang John R. Subjeck Anurag K. Singh Elizabeth A. Repasky
author_facet	Minhui Chen Guanxi Qiao Bonnie L. Hylander Hemn Mohammadpour Xiang-Yang Wang John R. Subjeck Anurag K. Singh Elizabeth A. Repasky
author_sort	Minhui Chen
title	Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
title_short	Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
title_full	Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
title_fullStr	Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
title_full_unstemmed	Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
title_sort	adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bf540c3fc9a8411c9f4089714a3b4c2c
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Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation

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