Concentration-Dependent Fluorescence Emission of Quercetin

Quercetin (Q) is an important antioxidant with high bioactivity and the potential of being used as SARS-CoV-2 inhibitor. The fluorescence (FL) emission from Q solutions made with different polar and non-polar solvents (methanol, acetone, and chloroform) was measured and compared with the FL emission...

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Autores principales:	Tatiana Prutskij, Alexandra Deriabina, Francisco J. Melendez, María Eugenia Castro, Leticia Castillo Trejo, German D. Vazquez Leon, Eduardo Gonzalez, Tatiana S. Perova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	quercetin fluorescence emission bioactivity antioxidants TDDFT ESIPT Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/bf548780e92341779515639594e33dfa
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spelling	oai:doaj.org-article:bf548780e92341779515639594e33dfa2021-11-25T17:13:38ZConcentration-Dependent Fluorescence Emission of Quercetin10.3390/chemosensors91103152227-9040https://doaj.org/article/bf548780e92341779515639594e33dfa2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9040/9/11/315https://doaj.org/toc/2227-9040Quercetin (Q) is an important antioxidant with high bioactivity and the potential of being used as SARS-CoV-2 inhibitor. The fluorescence (FL) emission from Q solutions made with different polar and non-polar solvents (methanol, acetone, and chloroform) was measured and compared with the FL emission from Q powder and from Q crystals. In the FL spectra of the solutions with high Q concentration, as well as in the spectra of Q in solid state, two features, at 615 nm and 670 nm, were observed. As the solution concentration decreases, the intensity of those peaks decreases and a peak at 505 nm arises. The FL emission of low concentration solutions displayed only that peak. Calculations for the Q molecule in each solvent, performed using time-dependent density functional theory (TDDFT), show that the emission at 505 nm is associated with the excited state intramolecular proton transfer (ESIPT) of the –OH3 group proton. Our calculations also show that the feature at 615 nm, which is observed in solid state Q and also in the emission of the high concentrated solutions, is related to the –OH5 proton transfer.Tatiana PrutskijAlexandra DeriabinaFrancisco J. MelendezMaría Eugenia CastroLeticia Castillo TrejoGerman D. Vazquez LeonEduardo GonzalezTatiana S. PerovaMDPI AGarticlequercetinfluorescence emissionbioactivityantioxidantsTDDFTESIPTBiochemistryQD415-436ENChemosensors, Vol 9, Iss 315, p 315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	quercetin fluorescence emission bioactivity antioxidants TDDFT ESIPT Biochemistry QD415-436
spellingShingle	quercetin fluorescence emission bioactivity antioxidants TDDFT ESIPT Biochemistry QD415-436 Tatiana Prutskij Alexandra Deriabina Francisco J. Melendez María Eugenia Castro Leticia Castillo Trejo German D. Vazquez Leon Eduardo Gonzalez Tatiana S. Perova Concentration-Dependent Fluorescence Emission of Quercetin
description	Quercetin (Q) is an important antioxidant with high bioactivity and the potential of being used as SARS-CoV-2 inhibitor. The fluorescence (FL) emission from Q solutions made with different polar and non-polar solvents (methanol, acetone, and chloroform) was measured and compared with the FL emission from Q powder and from Q crystals. In the FL spectra of the solutions with high Q concentration, as well as in the spectra of Q in solid state, two features, at 615 nm and 670 nm, were observed. As the solution concentration decreases, the intensity of those peaks decreases and a peak at 505 nm arises. The FL emission of low concentration solutions displayed only that peak. Calculations for the Q molecule in each solvent, performed using time-dependent density functional theory (TDDFT), show that the emission at 505 nm is associated with the excited state intramolecular proton transfer (ESIPT) of the –OH3 group proton. Our calculations also show that the feature at 615 nm, which is observed in solid state Q and also in the emission of the high concentrated solutions, is related to the –OH5 proton transfer.
format	article
author	Tatiana Prutskij Alexandra Deriabina Francisco J. Melendez María Eugenia Castro Leticia Castillo Trejo German D. Vazquez Leon Eduardo Gonzalez Tatiana S. Perova
author_facet	Tatiana Prutskij Alexandra Deriabina Francisco J. Melendez María Eugenia Castro Leticia Castillo Trejo German D. Vazquez Leon Eduardo Gonzalez Tatiana S. Perova
author_sort	Tatiana Prutskij
title	Concentration-Dependent Fluorescence Emission of Quercetin
title_short	Concentration-Dependent Fluorescence Emission of Quercetin
title_full	Concentration-Dependent Fluorescence Emission of Quercetin
title_fullStr	Concentration-Dependent Fluorescence Emission of Quercetin
title_full_unstemmed	Concentration-Dependent Fluorescence Emission of Quercetin
title_sort	concentration-dependent fluorescence emission of quercetin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf548780e92341779515639594e33dfa
work_keys_str_mv	AT tatianaprutskij concentrationdependentfluorescenceemissionofquercetin AT alexandraderiabina concentrationdependentfluorescenceemissionofquercetin AT franciscojmelendez concentrationdependentfluorescenceemissionofquercetin AT mariaeugeniacastro concentrationdependentfluorescenceemissionofquercetin AT leticiacastillotrejo concentrationdependentfluorescenceemissionofquercetin AT germandvazquezleon concentrationdependentfluorescenceemissionofquercetin AT eduardogonzalez concentrationdependentfluorescenceemissionofquercetin AT tatianasperova concentrationdependentfluorescenceemissionofquercetin
_version_	1718412616281358336

Concentration-Dependent Fluorescence Emission of Quercetin

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