EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE

Objective: To determine the frequency of different neurological features in Hashimoto's encephalopathy and to evaluate association with underling disease. Study Design: Cross sectional study. Place and Duration of Study: A Three-year study from Jul 2015 to Jul 2018. Conducted in Pak Emira...

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Autores principales:	Asif Hashmat, Wasim Alamgir, Saeed Arif, Jahanzeb Liaqat
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	hashimoto’s encephalopathy non-vasculitic autoimmune inflammatory meningoencephalitis (naim) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bf5562c0886c4d32b96a296a45cbccd9
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spelling	oai:doaj.org-article:bf5562c0886c4d32b96a296a45cbccd92021-11-09T02:49:11ZEVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE0030-96482411-8842https://doaj.org/article/bf5562c0886c4d32b96a296a45cbccd92019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3397/2372https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of different neurological features in Hashimoto's encephalopathy and to evaluate association with underling disease. Study Design: Cross sectional study. Place and Duration of Study: A Three-year study from Jul 2015 to Jul 2018. Conducted in Pak Emirates Military Hospital (PEMH) Rawalpindi. Methodology: This study is comprised of diagnosed patients of Hashimoto's encephalopathy. These patients fulfilled the diagnostic criteria. Any case with metabolic, toxic, vascular or malignant etiology of encephalopathy was excluded. Data regarding clinical symptoms particularly neurological and neuropsychiatric features, of diagnosed cases with Hashimoto’s encephalopathy was obtained from hospital record. Moreover, data about antithyroid antibody type, cerebrospinal fluid analysis, and MRI findings was gathered. Gender and age of the patients were also mentioned. Data was gathered on proforma by a resident doctor. The analysis was carried out using SPSS 20. Results were mentioned in the form of the mean for variables like age and percentage and frequencies for categorical variables. Results: Out of 13 patients, 5 (38.5%) were male and 8 (61.5%) were females. Majority of the patients 8 (61.5%) were euthyroid. Neuropsychiatric symptoms were present in all 13 patients with depression present in 8 (61.5%) cases, while 5 (38.4%) had hallucinations. Most cases were cognitively normal 8 (61.5%), while rest had mild impairment. No neurological manifestation was found significantly more common in any of the thyroid disease. Migraine-like headaches was present in 4 (30.7%) cases while epileptic seizures were present in 8 (61.5%) patients with GTCS the most common seizures type in 3 (23%) patients. Only three patient had MRI changes including temporal and hippocampal T2WI hyperintensities. Conclusion: If etiological factors for encephalopathy has been ruled out in the presence of underlying thyroid disease with a short history of symptoms, one should have a low threshold for treatment with the steroid to observe for the response.Asif HashmatWasim AlamgirSaeed ArifJahanzeb LiaqatArmy Medical College Rawalpindiarticlehashimoto’s encephalopathynon-vasculitic autoimmune inflammatory meningoencephalitis (naim)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 971-976 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hashimoto’s encephalopathy non-vasculitic autoimmune inflammatory meningoencephalitis (naim) Medicine R Medicine (General) R5-920
spellingShingle	hashimoto’s encephalopathy non-vasculitic autoimmune inflammatory meningoencephalitis (naim) Medicine R Medicine (General) R5-920 Asif Hashmat Wasim Alamgir Saeed Arif Jahanzeb Liaqat EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE
description	Objective: To determine the frequency of different neurological features in Hashimoto's encephalopathy and to evaluate association with underling disease. Study Design: Cross sectional study. Place and Duration of Study: A Three-year study from Jul 2015 to Jul 2018. Conducted in Pak Emirates Military Hospital (PEMH) Rawalpindi. Methodology: This study is comprised of diagnosed patients of Hashimoto's encephalopathy. These patients fulfilled the diagnostic criteria. Any case with metabolic, toxic, vascular or malignant etiology of encephalopathy was excluded. Data regarding clinical symptoms particularly neurological and neuropsychiatric features, of diagnosed cases with Hashimoto’s encephalopathy was obtained from hospital record. Moreover, data about antithyroid antibody type, cerebrospinal fluid analysis, and MRI findings was gathered. Gender and age of the patients were also mentioned. Data was gathered on proforma by a resident doctor. The analysis was carried out using SPSS 20. Results were mentioned in the form of the mean for variables like age and percentage and frequencies for categorical variables. Results: Out of 13 patients, 5 (38.5%) were male and 8 (61.5%) were females. Majority of the patients 8 (61.5%) were euthyroid. Neuropsychiatric symptoms were present in all 13 patients with depression present in 8 (61.5%) cases, while 5 (38.4%) had hallucinations. Most cases were cognitively normal 8 (61.5%), while rest had mild impairment. No neurological manifestation was found significantly more common in any of the thyroid disease. Migraine-like headaches was present in 4 (30.7%) cases while epileptic seizures were present in 8 (61.5%) patients with GTCS the most common seizures type in 3 (23%) patients. Only three patient had MRI changes including temporal and hippocampal T2WI hyperintensities. Conclusion: If etiological factors for encephalopathy has been ruled out in the presence of underlying thyroid disease with a short history of symptoms, one should have a low threshold for treatment with the steroid to observe for the response.
format	article
author	Asif Hashmat Wasim Alamgir Saeed Arif Jahanzeb Liaqat
author_facet	Asif Hashmat Wasim Alamgir Saeed Arif Jahanzeb Liaqat
author_sort	Asif Hashmat
title	EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE
title_short	EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE
title_full	EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE
title_fullStr	EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE
title_full_unstemmed	EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE
title_sort	evaluation of clinical symptomatology in patients with hashimoto's encephalopathy and association with underling thyroid disease
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/bf5562c0886c4d32b96a296a45cbccd9
work_keys_str_mv	AT asifhashmat evaluationofclinicalsymptomatologyinpatientswithhashimotosencephalopathyandassociationwithunderlingthyroiddisease AT wasimalamgir evaluationofclinicalsymptomatologyinpatientswithhashimotosencephalopathyandassociationwithunderlingthyroiddisease AT saeedarif evaluationofclinicalsymptomatologyinpatientswithhashimotosencephalopathyandassociationwithunderlingthyroiddisease AT jahanzebliaqat evaluationofclinicalsymptomatologyinpatientswithhashimotosencephalopathyandassociationwithunderlingthyroiddisease
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EVALUATION OF CLINICAL SYMPTOMATOLOGY IN PATIENTS WITH HASHIMOTO'S ENCEPHALOPATHY AND ASSOCIATION WITH UNDERLING THYROID DISEASE

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