SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitochondria, which inhibits apoptotic cell death.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bf575d4233b14e5f997658655553d914 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bf575d4233b14e5f997658655553d914 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bf575d4233b14e5f997658655553d9142021-12-02T18:50:04ZSMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria10.1038/s41467-021-25260-92041-1723https://doaj.org/article/bf575d4233b14e5f997658655553d9142021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25260-9https://doaj.org/toc/2041-1723SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitochondria, which inhibits apoptotic cell death.Yibo XueJordan L. MorrisKangning YangZheng FuXianbing ZhuFraser JohnsonBrian MeehanLeora WitkowskiAmber YasmeenTunde GolenarMackenzie CoathamGeneviève MorinAnie MonastVirginie PilonPierre Olivier FisetSungmi JungAnne V. GonzalezSophie Camilleri-BroetLili FuLynne-Marie PostovitJonathan SpicerWalter H. GotliebMarie-Christine GuiotJanusz RakMorag ParkWilliam LockwoodWilliam D. FoulkesJulien PrudentSidong HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yibo Xue Jordan L. Morris Kangning Yang Zheng Fu Xianbing Zhu Fraser Johnson Brian Meehan Leora Witkowski Amber Yasmeen Tunde Golenar Mackenzie Coatham Geneviève Morin Anie Monast Virginie Pilon Pierre Olivier Fiset Sungmi Jung Anne V. Gonzalez Sophie Camilleri-Broet Lili Fu Lynne-Marie Postovit Jonathan Spicer Walter H. Gotlieb Marie-Christine Guiot Janusz Rak Morag Park William Lockwood William D. Foulkes Julien Prudent Sidong Huang SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria |
| description |
SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitochondria, which inhibits apoptotic cell death. |
| format |
article |
| author |
Yibo Xue Jordan L. Morris Kangning Yang Zheng Fu Xianbing Zhu Fraser Johnson Brian Meehan Leora Witkowski Amber Yasmeen Tunde Golenar Mackenzie Coatham Geneviève Morin Anie Monast Virginie Pilon Pierre Olivier Fiset Sungmi Jung Anne V. Gonzalez Sophie Camilleri-Broet Lili Fu Lynne-Marie Postovit Jonathan Spicer Walter H. Gotlieb Marie-Christine Guiot Janusz Rak Morag Park William Lockwood William D. Foulkes Julien Prudent Sidong Huang |
| author_facet |
Yibo Xue Jordan L. Morris Kangning Yang Zheng Fu Xianbing Zhu Fraser Johnson Brian Meehan Leora Witkowski Amber Yasmeen Tunde Golenar Mackenzie Coatham Geneviève Morin Anie Monast Virginie Pilon Pierre Olivier Fiset Sungmi Jung Anne V. Gonzalez Sophie Camilleri-Broet Lili Fu Lynne-Marie Postovit Jonathan Spicer Walter H. Gotlieb Marie-Christine Guiot Janusz Rak Morag Park William Lockwood William D. Foulkes Julien Prudent Sidong Huang |
| author_sort |
Yibo Xue |
| title |
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria |
| title_short |
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria |
| title_full |
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria |
| title_fullStr |
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria |
| title_full_unstemmed |
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria |
| title_sort |
smarca4/2 loss inhibits chemotherapy-induced apoptosis by restricting ip3r3-mediated ca2+ flux to mitochondria |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bf575d4233b14e5f997658655553d914 |
| work_keys_str_mv |
AT yiboxue smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT jordanlmorris smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT kangningyang smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT zhengfu smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT xianbingzhu smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT fraserjohnson smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT brianmeehan smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT leorawitkowski smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT amberyasmeen smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT tundegolenar smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT mackenziecoatham smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT genevievemorin smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT aniemonast smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT virginiepilon smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT pierreolivierfiset smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT sungmijung smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT annevgonzalez smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT sophiecamilleribroet smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT lilifu smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT lynnemariepostovit smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT jonathanspicer smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT walterhgotlieb smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT mariechristineguiot smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT januszrak smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT moragpark smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT williamlockwood smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT williamdfoulkes smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT julienprudent smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria AT sidonghuang smarca42lossinhibitschemotherapyinducedapoptosisbyrestrictingip3r3mediatedca2fluxtomitochondria |
| _version_ |
1718377529366020096 |