Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening

Abstract Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal...

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Autores principales:	Takashi Ibuka, Seiji Adachi, Yohei Horibe, Tomohiko Ohno, Masatoshi Mabuchi, Yusuke Suzuki, Osamu Yamauchi, Eri Takada, Midori Iwama, Koshiro Saito, Masamichi Arao, Koji Takai, Hiroshi Araki, Masahito Shimizu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf5916ec0aaa4ae3a67943561778b723
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spelling	oai:doaj.org-article:bf5916ec0aaa4ae3a67943561778b7232021-12-02T14:28:17ZEffects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening10.1038/s41598-021-83007-42045-2322https://doaj.org/article/bf5916ec0aaa4ae3a67943561778b7232021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83007-4https://doaj.org/toc/2045-2322Abstract Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.Takashi IbukaSeiji AdachiYohei HoribeTomohiko OhnoMasatoshi MabuchiYusuke SuzukiOsamu YamauchiEri TakadaMidori IwamaKoshiro SaitoMasamichi AraoKoji TakaiHiroshi ArakiMasahito ShimizuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Ibuka Seiji Adachi Yohei Horibe Tomohiko Ohno Masatoshi Mabuchi Yusuke Suzuki Osamu Yamauchi Eri Takada Midori Iwama Koshiro Saito Masamichi Arao Koji Takai Hiroshi Araki Masahito Shimizu Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
description	Abstract Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.
format	article
author	Takashi Ibuka Seiji Adachi Yohei Horibe Tomohiko Ohno Masatoshi Mabuchi Yusuke Suzuki Osamu Yamauchi Eri Takada Midori Iwama Koshiro Saito Masamichi Arao Koji Takai Hiroshi Araki Masahito Shimizu
author_facet	Takashi Ibuka Seiji Adachi Yohei Horibe Tomohiko Ohno Masatoshi Mabuchi Yusuke Suzuki Osamu Yamauchi Eri Takada Midori Iwama Koshiro Saito Masamichi Arao Koji Takai Hiroshi Araki Masahito Shimizu
author_sort	Takashi Ibuka
title	Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
title_short	Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
title_full	Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
title_fullStr	Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
title_full_unstemmed	Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
title_sort	effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf5916ec0aaa4ae3a67943561778b723
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Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening

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