Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats.
PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment. Risk characterization of NDL-PCBs is confounded by the presence of highly potent dioxin-like impurities. We used ultrapure PCB 180 to characterize its toxicity profile in a 28-d...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bf5d98a2a2714b9eac8e5ee07feeb4f4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bf5d98a2a2714b9eac8e5ee07feeb4f4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bf5d98a2a2714b9eac8e5ee07feeb4f42021-11-25T06:04:08ZToxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats.1932-620310.1371/journal.pone.0104639https://doaj.org/article/bf5d98a2a2714b9eac8e5ee07feeb4f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25137063/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment. Risk characterization of NDL-PCBs is confounded by the presence of highly potent dioxin-like impurities. We used ultrapure PCB 180 to characterize its toxicity profile in a 28-day repeat dose toxicity study in young adult rats extended to cover endocrine and behavioral effects. Using a loading dose/maintenance dose regimen, groups of 5 males and 5 females were given total doses of 0, 3, 10, 30, 100, 300, 1000 or 1700 mg PCB 180/kg body weight by gavage. Dose-responses were analyzed using benchmark dose modeling based on dose and adipose tissue PCB concentrations. Body weight gain was retarded at 1700 mg/kg during loading dosing, but recovered thereafter. The most sensitive endpoint of toxicity that was used for risk characterization was altered open field behavior in females; i.e. increased activity and distance moved in the inner zone of an open field suggesting altered emotional responses to unfamiliar environment and impaired behavioral inhibition. Other dose-dependent changes included decreased serum thyroid hormones with associated histopathological changes, altered tissue retinoid levels, decreased hematocrit and hemoglobin, decreased follicle stimulating hormone and luteinizing hormone levels in males and increased expression of DNA damage markers in liver of females. Dose-dependent hypertrophy of zona fasciculata cells was observed in adrenals suggesting activation of cortex. There were gender differences in sensitivity and toxicity profiles were partly different in males and females. PCB 180 adipose tissue concentrations were clearly above the general human population levels, but close to the levels in highly exposed populations. The results demonstrate a distinct toxicological profile of PCB 180 with lack of dioxin-like properties required for assignment of WHO toxic equivalency factor. However, PCB 180 shares several toxicological targets with dioxin-like compounds emphasizing the potential for interactions.Matti VilukselaPäivi HeikkinenLeo T M van der VenFilip RendelRobert RoosJavier EstebanMerja KorkalainenSanna LensuHanna M MiettinenKari SavolainenSatu SankariHellmuth LilienthalAnnika AdamssonJorma ToppariMaria HerlinMikko FinniläJuha TuukkanenHeather A LeslieTimo HamersGerd HamscherLauy Al-AnatiUlla SteniusKine-Susann DervolaInger-Lise BogenFrode FonnumPatrik L AnderssonDieter SchrenkKrister HalldinHelen HåkanssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104639 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Matti Viluksela Päivi Heikkinen Leo T M van der Ven Filip Rendel Robert Roos Javier Esteban Merja Korkalainen Sanna Lensu Hanna M Miettinen Kari Savolainen Satu Sankari Hellmuth Lilienthal Annika Adamsson Jorma Toppari Maria Herlin Mikko Finnilä Juha Tuukkanen Heather A Leslie Timo Hamers Gerd Hamscher Lauy Al-Anati Ulla Stenius Kine-Susann Dervola Inger-Lise Bogen Frode Fonnum Patrik L Andersson Dieter Schrenk Krister Halldin Helen Håkansson Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. |
| description |
PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment. Risk characterization of NDL-PCBs is confounded by the presence of highly potent dioxin-like impurities. We used ultrapure PCB 180 to characterize its toxicity profile in a 28-day repeat dose toxicity study in young adult rats extended to cover endocrine and behavioral effects. Using a loading dose/maintenance dose regimen, groups of 5 males and 5 females were given total doses of 0, 3, 10, 30, 100, 300, 1000 or 1700 mg PCB 180/kg body weight by gavage. Dose-responses were analyzed using benchmark dose modeling based on dose and adipose tissue PCB concentrations. Body weight gain was retarded at 1700 mg/kg during loading dosing, but recovered thereafter. The most sensitive endpoint of toxicity that was used for risk characterization was altered open field behavior in females; i.e. increased activity and distance moved in the inner zone of an open field suggesting altered emotional responses to unfamiliar environment and impaired behavioral inhibition. Other dose-dependent changes included decreased serum thyroid hormones with associated histopathological changes, altered tissue retinoid levels, decreased hematocrit and hemoglobin, decreased follicle stimulating hormone and luteinizing hormone levels in males and increased expression of DNA damage markers in liver of females. Dose-dependent hypertrophy of zona fasciculata cells was observed in adrenals suggesting activation of cortex. There were gender differences in sensitivity and toxicity profiles were partly different in males and females. PCB 180 adipose tissue concentrations were clearly above the general human population levels, but close to the levels in highly exposed populations. The results demonstrate a distinct toxicological profile of PCB 180 with lack of dioxin-like properties required for assignment of WHO toxic equivalency factor. However, PCB 180 shares several toxicological targets with dioxin-like compounds emphasizing the potential for interactions. |
| format |
article |
| author |
Matti Viluksela Päivi Heikkinen Leo T M van der Ven Filip Rendel Robert Roos Javier Esteban Merja Korkalainen Sanna Lensu Hanna M Miettinen Kari Savolainen Satu Sankari Hellmuth Lilienthal Annika Adamsson Jorma Toppari Maria Herlin Mikko Finnilä Juha Tuukkanen Heather A Leslie Timo Hamers Gerd Hamscher Lauy Al-Anati Ulla Stenius Kine-Susann Dervola Inger-Lise Bogen Frode Fonnum Patrik L Andersson Dieter Schrenk Krister Halldin Helen Håkansson |
| author_facet |
Matti Viluksela Päivi Heikkinen Leo T M van der Ven Filip Rendel Robert Roos Javier Esteban Merja Korkalainen Sanna Lensu Hanna M Miettinen Kari Savolainen Satu Sankari Hellmuth Lilienthal Annika Adamsson Jorma Toppari Maria Herlin Mikko Finnilä Juha Tuukkanen Heather A Leslie Timo Hamers Gerd Hamscher Lauy Al-Anati Ulla Stenius Kine-Susann Dervola Inger-Lise Bogen Frode Fonnum Patrik L Andersson Dieter Schrenk Krister Halldin Helen Håkansson |
| author_sort |
Matti Viluksela |
| title |
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. |
| title_short |
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. |
| title_full |
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. |
| title_fullStr |
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. |
| title_full_unstemmed |
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. |
| title_sort |
toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (pcb 180) in adult rats. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/bf5d98a2a2714b9eac8e5ee07feeb4f4 |
| work_keys_str_mv |
AT mattiviluksela toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT paiviheikkinen toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT leotmvanderven toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT filiprendel toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT robertroos toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT javieresteban toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT merjakorkalainen toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT sannalensu toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT hannammiettinen toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT karisavolainen toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT satusankari toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT hellmuthlilienthal toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT annikaadamsson toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT jormatoppari toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT mariaherlin toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT mikkofinnila toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT juhatuukkanen toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT heatheraleslie toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT timohamers toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT gerdhamscher toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT lauyalanati toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT ullastenius toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT kinesusanndervola toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT ingerlisebogen toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT frodefonnum toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT patriklandersson toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT dieterschrenk toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT kristerhalldin toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats AT helenhakansson toxicologicalprofileofultrapure2234455heptachlorbiphenylpcb180inadultrats |
| _version_ |
1718414244813209600 |