Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis

Kohei Saeki et al. present a mammary cell atlas derived from mouse and human single-cell RNA-sequence data. They characterize key life stages in which the mammary gland undergoes complex remodeling and, using breast cancer expression data, infer cells of origin for carcinogenesis of various breast c...

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Autores principales: Kohei Saeki, Gregory Chang, Noriko Kanaya, Xiwei Wu, Jinhui Wang, Lauren Bernal, Desiree Ha, Susan L. Neuhausen, Shiuan Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bf5f51d3ae774ad78c6e50dc269ae7a4
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spelling oai:doaj.org-article:bf5f51d3ae774ad78c6e50dc269ae7a42021-12-02T17:51:20ZMammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis10.1038/s42003-021-02201-22399-3642https://doaj.org/article/bf5f51d3ae774ad78c6e50dc269ae7a42021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02201-2https://doaj.org/toc/2399-3642Kohei Saeki et al. present a mammary cell atlas derived from mouse and human single-cell RNA-sequence data. They characterize key life stages in which the mammary gland undergoes complex remodeling and, using breast cancer expression data, infer cells of origin for carcinogenesis of various breast cancer subtypes.Kohei SaekiGregory ChangNoriko KanayaXiwei WuJinhui WangLauren BernalDesiree HaSusan L. NeuhausenShiuan ChenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Kohei Saeki
Gregory Chang
Noriko Kanaya
Xiwei Wu
Jinhui Wang
Lauren Bernal
Desiree Ha
Susan L. Neuhausen
Shiuan Chen
Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
description Kohei Saeki et al. present a mammary cell atlas derived from mouse and human single-cell RNA-sequence data. They characterize key life stages in which the mammary gland undergoes complex remodeling and, using breast cancer expression data, infer cells of origin for carcinogenesis of various breast cancer subtypes.
format article
author Kohei Saeki
Gregory Chang
Noriko Kanaya
Xiwei Wu
Jinhui Wang
Lauren Bernal
Desiree Ha
Susan L. Neuhausen
Shiuan Chen
author_facet Kohei Saeki
Gregory Chang
Noriko Kanaya
Xiwei Wu
Jinhui Wang
Lauren Bernal
Desiree Ha
Susan L. Neuhausen
Shiuan Chen
author_sort Kohei Saeki
title Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
title_short Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
title_full Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
title_fullStr Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
title_full_unstemmed Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
title_sort mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bf5f51d3ae774ad78c6e50dc269ae7a4
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AT norikokanaya mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
AT xiweiwu mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
AT jinhuiwang mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
AT laurenbernal mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
AT desireeha mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
AT susanlneuhausen mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
AT shiuanchen mammarycellgeneexpressionatlaslinksepithelialcellremodelingeventstobreastcarcinogenesis
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