The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

TRAF6 is a ubiquitin E3 ligase regulating a number of biological processes. Here the authors show that ROS, generated during pathological cardiac stress, induces TRAF6 auto-ubiquitination and activation, promoting its interaction with and ubiquitination of TAK1 that contributes to development of car...

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Autores principales: Yan-Xiao Ji, Peng Zhang, Xiao-Jing Zhang, Yi-Chao Zhao, Ke-Qiong Deng, Xi Jiang, Pi-Xiao Wang, Zan Huang, Hongliang Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/bf605e807c9540e797155442a3812052
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spelling oai:doaj.org-article:bf605e807c9540e797155442a38120522021-12-02T16:58:23ZThe ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling10.1038/ncomms112672041-1723https://doaj.org/article/bf605e807c9540e797155442a38120522016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11267https://doaj.org/toc/2041-1723TRAF6 is a ubiquitin E3 ligase regulating a number of biological processes. Here the authors show that ROS, generated during pathological cardiac stress, induces TRAF6 auto-ubiquitination and activation, promoting its interaction with and ubiquitination of TAK1 that contributes to development of cardiac hypertrophy.Yan-Xiao JiPeng ZhangXiao-Jing ZhangYi-Chao ZhaoKe-Qiong DengXi JiangPi-Xiao WangZan HuangHongliang LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yan-Xiao Ji
Peng Zhang
Xiao-Jing Zhang
Yi-Chao Zhao
Ke-Qiong Deng
Xi Jiang
Pi-Xiao Wang
Zan Huang
Hongliang Li
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
description TRAF6 is a ubiquitin E3 ligase regulating a number of biological processes. Here the authors show that ROS, generated during pathological cardiac stress, induces TRAF6 auto-ubiquitination and activation, promoting its interaction with and ubiquitination of TAK1 that contributes to development of cardiac hypertrophy.
format article
author Yan-Xiao Ji
Peng Zhang
Xiao-Jing Zhang
Yi-Chao Zhao
Ke-Qiong Deng
Xi Jiang
Pi-Xiao Wang
Zan Huang
Hongliang Li
author_facet Yan-Xiao Ji
Peng Zhang
Xiao-Jing Zhang
Yi-Chao Zhao
Ke-Qiong Deng
Xi Jiang
Pi-Xiao Wang
Zan Huang
Hongliang Li
author_sort Yan-Xiao Ji
title The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
title_short The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
title_full The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
title_fullStr The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
title_full_unstemmed The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
title_sort ubiquitin e3 ligase traf6 exacerbates pathological cardiac hypertrophy via tak1-dependent signalling
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/bf605e807c9540e797155442a3812052
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