Local effects of adipose tissue in psoriasis and psoriatic arthritis

Ilja L Kruglikov,1 Uwe Wollina2 1Scientific Department, Wellcomet GmbH, Karlsruhe, 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany Abstract: The structure and physiological state of the lo...

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Autores principales:	Kruglikov IL, Wollina U
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	psoriasis – psoriatic arthritis - pathophysiology - adipose tissue - dermal adipocytes - articular adipose tissue Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/bf64f91d1488477881a8ff1ef3f48d6a
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spelling	oai:doaj.org-article:bf64f91d1488477881a8ff1ef3f48d6a2021-12-02T05:32:57ZLocal effects of adipose tissue in psoriasis and psoriatic arthritis2230-326Xhttps://doaj.org/article/bf64f91d1488477881a8ff1ef3f48d6a2017-02-01T00:00:00Zhttps://www.dovepress.com/local-effects-of-adipose-tissue-in-psoriasis-and-psoriatic-arthritis-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XIlja L Kruglikov,1 Uwe Wollina2 1Scientific Department, Wellcomet GmbH, Karlsruhe, 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany Abstract: The structure and physiological state of the local white adipose tissue (WAT) located underneath the lesional psoriatic skin and inside of the joints affected by psoriatic arthritis play an important role in the pathophysiology of these diseases. WAT pads associated with inflammatory sites in psoriasis and psoriatic arthritis are, correspondingly, dermal WAT and articular adipose tissue; these pads demonstrate inflammatory phenotypes in both diseases. Such local WAT inflammation could be the primary effect in the pathophysiology of psoriasis leading to the modification of the local expression of adipokines, a change in the structure of the basement membrane and the release of keratinocytes with consequent epidermal hyperproliferation during psoriasis. Similar articular adipose tissue inflammation can lead to the induction of structural modifications and synovial inflammation in the joints of patients with psoriatic arthritis. Keywords: psoriasis, psoriatic arthritis, pathophysiology, adipose tissue, dermal adipocytes, articular adipose tissueKruglikov ILWollina UDove Medical Pressarticlepsoriasis – psoriatic arthritis - pathophysiology - adipose tissue - dermal adipocytes - articular adipose tissueDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 7, Pp 17-25 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis – psoriatic arthritis - pathophysiology - adipose tissue - dermal adipocytes - articular adipose tissue Dermatology RL1-803
spellingShingle	psoriasis – psoriatic arthritis - pathophysiology - adipose tissue - dermal adipocytes - articular adipose tissue Dermatology RL1-803 Kruglikov IL Wollina U Local effects of adipose tissue in psoriasis and psoriatic arthritis
description	Ilja L Kruglikov,1 Uwe Wollina2 1Scientific Department, Wellcomet GmbH, Karlsruhe, 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany Abstract: The structure and physiological state of the local white adipose tissue (WAT) located underneath the lesional psoriatic skin and inside of the joints affected by psoriatic arthritis play an important role in the pathophysiology of these diseases. WAT pads associated with inflammatory sites in psoriasis and psoriatic arthritis are, correspondingly, dermal WAT and articular adipose tissue; these pads demonstrate inflammatory phenotypes in both diseases. Such local WAT inflammation could be the primary effect in the pathophysiology of psoriasis leading to the modification of the local expression of adipokines, a change in the structure of the basement membrane and the release of keratinocytes with consequent epidermal hyperproliferation during psoriasis. Similar articular adipose tissue inflammation can lead to the induction of structural modifications and synovial inflammation in the joints of patients with psoriatic arthritis. Keywords: psoriasis, psoriatic arthritis, pathophysiology, adipose tissue, dermal adipocytes, articular adipose tissue
format	article
author	Kruglikov IL Wollina U
author_facet	Kruglikov IL Wollina U
author_sort	Kruglikov IL
title	Local effects of adipose tissue in psoriasis and psoriatic arthritis
title_short	Local effects of adipose tissue in psoriasis and psoriatic arthritis
title_full	Local effects of adipose tissue in psoriasis and psoriatic arthritis
title_fullStr	Local effects of adipose tissue in psoriasis and psoriatic arthritis
title_full_unstemmed	Local effects of adipose tissue in psoriasis and psoriatic arthritis
title_sort	local effects of adipose tissue in psoriasis and psoriatic arthritis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/bf64f91d1488477881a8ff1ef3f48d6a
work_keys_str_mv	AT kruglikovil localeffectsofadiposetissueinpsoriasisandpsoriaticarthritis AT wollinau localeffectsofadiposetissueinpsoriasisandpsoriaticarthritis
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Local effects of adipose tissue in psoriasis and psoriatic arthritis

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