Emerging Pathological Engagement of Ferroptosis in Gut Diseases

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is mainly characterized by chronic and progressive inflammation that damages the gastrointestinal mucosa. Increasing studies have enlightened that dysregulated cell death occurs in the inflamed sites, leading to the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weihua Gao, Ting Zhang, Hao Wu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/bf658bf539de4d6990b15351fbb06495
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf658bf539de4d6990b15351fbb06495
record_format	dspace
spelling	oai:doaj.org-article:bf658bf539de4d6990b15351fbb064952021-11-08T02:36:34ZEmerging Pathological Engagement of Ferroptosis in Gut Diseases1942-099410.1155/2021/4246255https://doaj.org/article/bf658bf539de4d6990b15351fbb064952021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4246255https://doaj.org/toc/1942-0994Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is mainly characterized by chronic and progressive inflammation that damages the gastrointestinal mucosa. Increasing studies have enlightened that dysregulated cell death occurs in the inflamed sites, leading to the disruption of the intestinal barrier and aggravating inflammatory response. Ferroptosis, a newly characterized form of regulated cell death, is driven by the lethal accumulation of lipid peroxides catalyzed by cellular free iron. It has been widely documented that the fundamental features of ferroptosis, including iron deposition, GSH exhaustion, GPX4 inactivation, and lipid peroxidation, are manifested in the injured gastrointestinal tract in IBD patients. Furthermore, manipulation of the critical ferroptotic genes could alter the progression, severity, or even morbidity of the experimental colitis. Herein, we critically summarize the recent advances in the field of ferroptosis, focusing on interpreting the potential engagement of ferroptosis in the pathogenesis of IBD. Moreover, we are attempting to shed light on a perspective insight into the possibility of targeting ferroptosis as novel therapeutic designs for the clinical intervention of these gastrointestinal diseases.Weihua GaoTing ZhangHao WuHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Weihua Gao Ting Zhang Hao Wu Emerging Pathological Engagement of Ferroptosis in Gut Diseases
description	Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is mainly characterized by chronic and progressive inflammation that damages the gastrointestinal mucosa. Increasing studies have enlightened that dysregulated cell death occurs in the inflamed sites, leading to the disruption of the intestinal barrier and aggravating inflammatory response. Ferroptosis, a newly characterized form of regulated cell death, is driven by the lethal accumulation of lipid peroxides catalyzed by cellular free iron. It has been widely documented that the fundamental features of ferroptosis, including iron deposition, GSH exhaustion, GPX4 inactivation, and lipid peroxidation, are manifested in the injured gastrointestinal tract in IBD patients. Furthermore, manipulation of the critical ferroptotic genes could alter the progression, severity, or even morbidity of the experimental colitis. Herein, we critically summarize the recent advances in the field of ferroptosis, focusing on interpreting the potential engagement of ferroptosis in the pathogenesis of IBD. Moreover, we are attempting to shed light on a perspective insight into the possibility of targeting ferroptosis as novel therapeutic designs for the clinical intervention of these gastrointestinal diseases.
format	article
author	Weihua Gao Ting Zhang Hao Wu
author_facet	Weihua Gao Ting Zhang Hao Wu
author_sort	Weihua Gao
title	Emerging Pathological Engagement of Ferroptosis in Gut Diseases
title_short	Emerging Pathological Engagement of Ferroptosis in Gut Diseases
title_full	Emerging Pathological Engagement of Ferroptosis in Gut Diseases
title_fullStr	Emerging Pathological Engagement of Ferroptosis in Gut Diseases
title_full_unstemmed	Emerging Pathological Engagement of Ferroptosis in Gut Diseases
title_sort	emerging pathological engagement of ferroptosis in gut diseases
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/bf658bf539de4d6990b15351fbb06495
work_keys_str_mv	AT weihuagao emergingpathologicalengagementofferroptosisingutdiseases AT tingzhang emergingpathologicalengagementofferroptosisingutdiseases AT haowu emergingpathologicalengagementofferroptosisingutdiseases
_version_	1718443132773728256

Emerging Pathological Engagement of Ferroptosis in Gut Diseases

Ejemplares similares