Complete mitochondrial DNA diversity in Iranians.

Due to its pivotal geographical location and proximity to transcontinental migratory routes, Iran has played a key role in subsequent migrations, both prehistoric and historic, between Africa, Asia and Europe. To shed light on the genetic structure of the Iranian population as well as on the expansi...

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Autores principales:	Miroslava Derenko, Boris Malyarchuk, Ardeshir Bahmanimehr, Galina Denisova, Maria Perkova, Shirin Farjadian, Levon Yepiskoposyan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf70f9e4a3ca4313a4bac774aeb29779
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spelling	oai:doaj.org-article:bf70f9e4a3ca4313a4bac774aeb297792021-11-18T08:46:24ZComplete mitochondrial DNA diversity in Iranians.1932-620310.1371/journal.pone.0080673https://doaj.org/article/bf70f9e4a3ca4313a4bac774aeb297792013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244704/?tool=EBIhttps://doaj.org/toc/1932-6203Due to its pivotal geographical location and proximity to transcontinental migratory routes, Iran has played a key role in subsequent migrations, both prehistoric and historic, between Africa, Asia and Europe. To shed light on the genetic structure of the Iranian population as well as on the expansion patterns and population movements which affected this region, the complete mitochondrial genomes of 352 Iranians were obtained. All Iranian populations studied here exhibit similarly high diversity values comparable to the other groups from the Caucasus, Anatolia and Europe. The results of AMOVA and MDS analyses did not associate any regional and/or linguistic group of populations in the Anatolia/Caucasus and Iran region pointing to close genetic positions of Persians and Qashqais to each other and to Armenians, and Azeris from Iran to Georgians. By reconstructing the complete mtDNA phylogeny of haplogroups R2, N3, U1, U3, U5a1g, U7, H13, HV2, HV12, M5a and C5c we have found a previously unexplored genetic connection between the studied Iranian populations and the Arabian Peninsula, India, Near East and Europe, likely the result of both ancient and recent gene flow. Our results for Persians and Qashqais point to a continuous increase of the population sizes from ∼24 kya to the present, although the phase between 14-24 kya is thought to be hyperarid according to the Gulf Oasis model. Since this would have affected hunter-gatherer ranges and mobility patterns and forced them to increasingly rely on coastal resources, this transition can explain the human expansion across the Persian Gulf region.Miroslava DerenkoBoris MalyarchukArdeshir BahmanimehrGalina DenisovaMaria PerkovaShirin FarjadianLevon YepiskoposyanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80673 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miroslava Derenko Boris Malyarchuk Ardeshir Bahmanimehr Galina Denisova Maria Perkova Shirin Farjadian Levon Yepiskoposyan Complete mitochondrial DNA diversity in Iranians.
description	Due to its pivotal geographical location and proximity to transcontinental migratory routes, Iran has played a key role in subsequent migrations, both prehistoric and historic, between Africa, Asia and Europe. To shed light on the genetic structure of the Iranian population as well as on the expansion patterns and population movements which affected this region, the complete mitochondrial genomes of 352 Iranians were obtained. All Iranian populations studied here exhibit similarly high diversity values comparable to the other groups from the Caucasus, Anatolia and Europe. The results of AMOVA and MDS analyses did not associate any regional and/or linguistic group of populations in the Anatolia/Caucasus and Iran region pointing to close genetic positions of Persians and Qashqais to each other and to Armenians, and Azeris from Iran to Georgians. By reconstructing the complete mtDNA phylogeny of haplogroups R2, N3, U1, U3, U5a1g, U7, H13, HV2, HV12, M5a and C5c we have found a previously unexplored genetic connection between the studied Iranian populations and the Arabian Peninsula, India, Near East and Europe, likely the result of both ancient and recent gene flow. Our results for Persians and Qashqais point to a continuous increase of the population sizes from ∼24 kya to the present, although the phase between 14-24 kya is thought to be hyperarid according to the Gulf Oasis model. Since this would have affected hunter-gatherer ranges and mobility patterns and forced them to increasingly rely on coastal resources, this transition can explain the human expansion across the Persian Gulf region.
format	article
author	Miroslava Derenko Boris Malyarchuk Ardeshir Bahmanimehr Galina Denisova Maria Perkova Shirin Farjadian Levon Yepiskoposyan
author_facet	Miroslava Derenko Boris Malyarchuk Ardeshir Bahmanimehr Galina Denisova Maria Perkova Shirin Farjadian Levon Yepiskoposyan
author_sort	Miroslava Derenko
title	Complete mitochondrial DNA diversity in Iranians.
title_short	Complete mitochondrial DNA diversity in Iranians.
title_full	Complete mitochondrial DNA diversity in Iranians.
title_fullStr	Complete mitochondrial DNA diversity in Iranians.
title_full_unstemmed	Complete mitochondrial DNA diversity in Iranians.
title_sort	complete mitochondrial dna diversity in iranians.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bf70f9e4a3ca4313a4bac774aeb29779
work_keys_str_mv	AT miroslavaderenko completemitochondrialdnadiversityiniranians AT borismalyarchuk completemitochondrialdnadiversityiniranians AT ardeshirbahmanimehr completemitochondrialdnadiversityiniranians AT galinadenisova completemitochondrialdnadiversityiniranians AT mariaperkova completemitochondrialdnadiversityiniranians AT shirinfarjadian completemitochondrialdnadiversityiniranians AT levonyepiskoposyan completemitochondrialdnadiversityiniranians
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Complete mitochondrial DNA diversity in Iranians.

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