Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia

Takaki Tanifuji,1 Satoshi Okazaki,1 Ikuo Otsuka,1 Tadasu Horai,1 Yutaka Shinko,1 Saehyeon Kim,1 Ichiro Sora,1 Akitoyo Hishimoto1,2 1Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan; 2Department of Psychiatry, Yokohama City University Graduate School of Medicine, Yok...

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Autores principales:	Tanifuji T, Okazaki S, Otsuka I, Horai T, Shinko Y, Kim S, Sora I, Hishimoto A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	haplotype monoamine oxidase a polymorphism schizophrenia variable number of tandem repeats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bf7265000b9349daa17656e0855a85af
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spelling	oai:doaj.org-article:bf7265000b9349daa17656e0855a85af2021-12-02T18:43:25ZAssociation of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia1178-2021https://doaj.org/article/bf7265000b9349daa17656e0855a85af2021-11-01T00:00:00Zhttps://www.dovepress.com/association-of-two-variable-number-of-tandem-repeats-in-the-monoamine--peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Takaki Tanifuji,1 Satoshi Okazaki,1 Ikuo Otsuka,1 Tadasu Horai,1 Yutaka Shinko,1 Saehyeon Kim,1 Ichiro Sora,1 Akitoyo Hishimoto1,2 1Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan; 2Department of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama, JapanCorrespondence: Akitoyo HishimotoDepartment of Psychiatry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, 236-0004, JapanTel +81-45-787-2667Fax +81-45-783-2540Email hishipon@yokohama-cu.ac.jpBackground: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Previous studies have reported that variable number of tandem repeats (VNTR), namely, upstream (u)VNTR, and some single nucleotide polymorphisms (SNPs) in the MAOA gene are associated with schizophrenia.Methods: We investigated the two VNTRs and their related SNPs (rs6323 and rs1137070) in the MAOA gene promoter in 859 patients with schizophrenia and 826 healthy controls. Distal (d)VNTR and uVNTR were genotyped with fluorescence-based fragment polymerase chain reaction assays, and rs6323 and rs1137070 with TaqMan SNP genotyping assays.Results: Neither the genotype nor allelic frequency of the VNTRs or SNPs showed significant differences between the schizophrenia and control groups. On the other hand, analysis of the dVNTR-uVNTR-rs6323-rs1137070 haplotype showed significant association for nine repeats (9R)-3R-T-C in female patients (corrected p = 0.0006, odds ratio [confidence interval] = 2.17 [1.446– 3.257]).Conclusion: Our findings provide novel evidence that MAOA gene polymorphisms are associated with an increased risk of developing schizophrenia in females.Keywords: haplotype, monoamine oxidase A, polymorphism, schizophrenia, variable number of tandem repeatsTanifuji TOkazaki SOtsuka IHorai TShinko YKim SSora IHishimoto ADove Medical Pressarticlehaplotypemonoamine oxidase apolymorphismschizophreniavariable number of tandem repeatsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3315-3323 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	haplotype monoamine oxidase a polymorphism schizophrenia variable number of tandem repeats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	haplotype monoamine oxidase a polymorphism schizophrenia variable number of tandem repeats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tanifuji T Okazaki S Otsuka I Horai T Shinko Y Kim S Sora I Hishimoto A Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia
description	Takaki Tanifuji,1 Satoshi Okazaki,1 Ikuo Otsuka,1 Tadasu Horai,1 Yutaka Shinko,1 Saehyeon Kim,1 Ichiro Sora,1 Akitoyo Hishimoto1,2 1Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan; 2Department of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama, JapanCorrespondence: Akitoyo HishimotoDepartment of Psychiatry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, 236-0004, JapanTel +81-45-787-2667Fax +81-45-783-2540Email hishipon@yokohama-cu.ac.jpBackground: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Previous studies have reported that variable number of tandem repeats (VNTR), namely, upstream (u)VNTR, and some single nucleotide polymorphisms (SNPs) in the MAOA gene are associated with schizophrenia.Methods: We investigated the two VNTRs and their related SNPs (rs6323 and rs1137070) in the MAOA gene promoter in 859 patients with schizophrenia and 826 healthy controls. Distal (d)VNTR and uVNTR were genotyped with fluorescence-based fragment polymerase chain reaction assays, and rs6323 and rs1137070 with TaqMan SNP genotyping assays.Results: Neither the genotype nor allelic frequency of the VNTRs or SNPs showed significant differences between the schizophrenia and control groups. On the other hand, analysis of the dVNTR-uVNTR-rs6323-rs1137070 haplotype showed significant association for nine repeats (9R)-3R-T-C in female patients (corrected p = 0.0006, odds ratio [confidence interval] = 2.17 [1.446– 3.257]).Conclusion: Our findings provide novel evidence that MAOA gene polymorphisms are associated with an increased risk of developing schizophrenia in females.Keywords: haplotype, monoamine oxidase A, polymorphism, schizophrenia, variable number of tandem repeats
format	article
author	Tanifuji T Okazaki S Otsuka I Horai T Shinko Y Kim S Sora I Hishimoto A
author_facet	Tanifuji T Okazaki S Otsuka I Horai T Shinko Y Kim S Sora I Hishimoto A
author_sort	Tanifuji T
title	Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia
title_short	Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia
title_full	Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia
title_fullStr	Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia
title_full_unstemmed	Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia
title_sort	association of two variable number of tandem repeats in the monoamine oxidase a gene promoter with schizophrenia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bf7265000b9349daa17656e0855a85af
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Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia

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