Polymeric stents for the Eustachian tube: development and human cadaver study

Impairment of Eustachian tube function with nonsufficient ventilation of the middle ear is a main cause for chronic otitis media. To provide an effective and safe therapy, the innovative concept of Eustachian tube stenting was established. Biodegradable polymeric stents are developed to restore impa...

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Autores principales:	Schümann Kerstin, Wilfling Tamara, Paasche Gerrit, Schuon Robert, Lenarz Thomas, Tautorat Carsten, Grabow Niels, Schmitz Klaus-Peter
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	eustachian tube dysfunction polymeric stent cadaver study radiopaque marker diaphanoscopy Medicine R
Acceso en línea:	https://doaj.org/article/bf7729590cfe407e8fb61f3e782c1fd3
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spelling	oai:doaj.org-article:bf7729590cfe407e8fb61f3e782c1fd32021-12-05T14:10:42ZPolymeric stents for the Eustachian tube: development and human cadaver study2364-550410.1515/cdbme-2020-3054https://doaj.org/article/bf7729590cfe407e8fb61f3e782c1fd32020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3054https://doaj.org/toc/2364-5504Impairment of Eustachian tube function with nonsufficient ventilation of the middle ear is a main cause for chronic otitis media. To provide an effective and safe therapy, the innovative concept of Eustachian tube stenting was established. Biodegradable polymeric stents are developed to restore impaired tube function and dissolve after fulfilling their supportive purpose. To evaluate the applicability of the stents in the Eustachian tube, prototypes in conjunction with corresponding implantation instruments were tested in human cadaver studies. Radiopaque markers and a diaphanoscopic approach were tested as additional features to prove correct positioning of catheter and stent in the tube. In the current study biodegradable polymeric stents were implanted in the Eustachian tube of human cadavers without difficulty. Correct positioning of the stents in the tube was proved by diaphanoscopy during intervention and postoperative tomographic and histological analyses. Once designs are optimized on the basis of cadaver studies, preclinical safety and efficacy studies using animal models will be initiated.Schümann KerstinWilfling TamaraPaasche GerritSchuon RobertLenarz ThomasTautorat CarstenGrabow NielsSchmitz Klaus-PeterDe Gruyterarticleeustachian tube dysfunctionpolymeric stentcadaver studyradiopaque markerdiaphanoscopyMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 213-216 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	eustachian tube dysfunction polymeric stent cadaver study radiopaque marker diaphanoscopy Medicine R
spellingShingle	eustachian tube dysfunction polymeric stent cadaver study radiopaque marker diaphanoscopy Medicine R Schümann Kerstin Wilfling Tamara Paasche Gerrit Schuon Robert Lenarz Thomas Tautorat Carsten Grabow Niels Schmitz Klaus-Peter Polymeric stents for the Eustachian tube: development and human cadaver study
description	Impairment of Eustachian tube function with nonsufficient ventilation of the middle ear is a main cause for chronic otitis media. To provide an effective and safe therapy, the innovative concept of Eustachian tube stenting was established. Biodegradable polymeric stents are developed to restore impaired tube function and dissolve after fulfilling their supportive purpose. To evaluate the applicability of the stents in the Eustachian tube, prototypes in conjunction with corresponding implantation instruments were tested in human cadaver studies. Radiopaque markers and a diaphanoscopic approach were tested as additional features to prove correct positioning of catheter and stent in the tube. In the current study biodegradable polymeric stents were implanted in the Eustachian tube of human cadavers without difficulty. Correct positioning of the stents in the tube was proved by diaphanoscopy during intervention and postoperative tomographic and histological analyses. Once designs are optimized on the basis of cadaver studies, preclinical safety and efficacy studies using animal models will be initiated.
format	article
author	Schümann Kerstin Wilfling Tamara Paasche Gerrit Schuon Robert Lenarz Thomas Tautorat Carsten Grabow Niels Schmitz Klaus-Peter
author_facet	Schümann Kerstin Wilfling Tamara Paasche Gerrit Schuon Robert Lenarz Thomas Tautorat Carsten Grabow Niels Schmitz Klaus-Peter
author_sort	Schümann Kerstin
title	Polymeric stents for the Eustachian tube: development and human cadaver study
title_short	Polymeric stents for the Eustachian tube: development and human cadaver study
title_full	Polymeric stents for the Eustachian tube: development and human cadaver study
title_fullStr	Polymeric stents for the Eustachian tube: development and human cadaver study
title_full_unstemmed	Polymeric stents for the Eustachian tube: development and human cadaver study
title_sort	polymeric stents for the eustachian tube: development and human cadaver study
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/bf7729590cfe407e8fb61f3e782c1fd3
work_keys_str_mv	AT schumannkerstin polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT wilflingtamara polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT paaschegerrit polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT schuonrobert polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT lenarzthomas polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT tautoratcarsten polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT grabowniels polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy AT schmitzklauspeter polymericstentsfortheeustachiantubedevelopmentandhumancadaverstudy
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Polymeric stents for the Eustachian tube: development and human cadaver study

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