ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS

Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone...

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Autores principales:	M. V. Kiselevsky, N. Yu. Anisimova, Yu. I. Dolzhikova, R. Ya. Vlasenko, F. S. Senatov, A. V. Karaulov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	mesenchymal multipotent stromal cells immunomodulating activity bone bioimplants osteoimmunology tissue engineering constructions Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bf77f7a4aea3429c8b14205dd82bb443
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spelling	oai:doaj.org-article:bf77f7a4aea3429c8b14205dd82bb4432021-11-18T08:03:47ZROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS1563-06252313-741X10.15789/1563-0625-2018-4-515-522https://doaj.org/article/bf77f7a4aea3429c8b14205dd82bb4432018-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1559https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbility of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneration.M. V. KiselevskyN. Yu. AnisimovaYu. I. DolzhikovaR. Ya. VlasenkoF. S. SenatovA. V. KaraulovSPb RAACIarticlemesenchymal multipotent stromal cellsimmunomodulating activitybone bioimplantsosteoimmunologytissue engineering constructionsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 4, Pp 515-522 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	mesenchymal multipotent stromal cells immunomodulating activity bone bioimplants osteoimmunology tissue engineering constructions Immunologic diseases. Allergy RC581-607
spellingShingle	mesenchymal multipotent stromal cells immunomodulating activity bone bioimplants osteoimmunology tissue engineering constructions Immunologic diseases. Allergy RC581-607 M. V. Kiselevsky N. Yu. Anisimova Yu. I. Dolzhikova R. Ya. Vlasenko F. S. Senatov A. V. Karaulov ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
description	Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneration.
format	article
author	M. V. Kiselevsky N. Yu. Anisimova Yu. I. Dolzhikova R. Ya. Vlasenko F. S. Senatov A. V. Karaulov
author_facet	M. V. Kiselevsky N. Yu. Anisimova Yu. I. Dolzhikova R. Ya. Vlasenko F. S. Senatov A. V. Karaulov
author_sort	M. V. Kiselevsky
title	ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
title_short	ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
title_full	ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
title_fullStr	ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
title_full_unstemmed	ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
title_sort	role of mesenchymal multipotent stromal cells in remodeling of bone defects
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/bf77f7a4aea3429c8b14205dd82bb443
work_keys_str_mv	AT mvkiselevsky roleofmesenchymalmultipotentstromalcellsinremodelingofbonedefects AT nyuanisimova roleofmesenchymalmultipotentstromalcellsinremodelingofbonedefects AT yuidolzhikova roleofmesenchymalmultipotentstromalcellsinremodelingofbonedefects AT ryavlasenko roleofmesenchymalmultipotentstromalcellsinremodelingofbonedefects AT fssenatov roleofmesenchymalmultipotentstromalcellsinremodelingofbonedefects AT avkaraulov roleofmesenchymalmultipotentstromalcellsinremodelingofbonedefects
_version_	1718422378010116096

ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS

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