Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories

Abstract Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP is observed as different profiles of Hebbian and anti-Hebbian learning rules. However, the specific roles of diverse STDP profiles in me...

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Autores principales:	Youngjin Park, Woochul Choi, Se-Bum Paik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf7a67b5367c4807be841317031f9def
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spelling	oai:doaj.org-article:bf7a67b5367c4807be841317031f9def2021-12-02T15:06:25ZSymmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories10.1038/s41598-017-05929-22045-2322https://doaj.org/article/bf7a67b5367c4807be841317031f9def2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05929-2https://doaj.org/toc/2045-2322Abstract Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP is observed as different profiles of Hebbian and anti-Hebbian learning rules. However, the specific roles of diverse STDP profiles in memory formation still remain elusive. Here, we show that the symmetry of the learning rate profile in STDP is crucial to determining the character of stored memory. Using computer simulations, we found that an asymmetric learning rate generates flexible memory that is volatile and easily overwritten by newly appended information. Moreover, a symmetric learning rate generates stable memory that can coexist with newly appended information. In addition, by combining these two conditions, we could realize a hybrid memory type that operates in a way intermediate between stable and flexible memory. Our results demonstrate that various attributes of memory functions may originate from differences in the synaptic stability.Youngjin ParkWoochul ChoiSe-Bum PaikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Youngjin Park Woochul Choi Se-Bum Paik Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
description	Abstract Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP is observed as different profiles of Hebbian and anti-Hebbian learning rules. However, the specific roles of diverse STDP profiles in memory formation still remain elusive. Here, we show that the symmetry of the learning rate profile in STDP is crucial to determining the character of stored memory. Using computer simulations, we found that an asymmetric learning rate generates flexible memory that is volatile and easily overwritten by newly appended information. Moreover, a symmetric learning rate generates stable memory that can coexist with newly appended information. In addition, by combining these two conditions, we could realize a hybrid memory type that operates in a way intermediate between stable and flexible memory. Our results demonstrate that various attributes of memory functions may originate from differences in the synaptic stability.
format	article
author	Youngjin Park Woochul Choi Se-Bum Paik
author_facet	Youngjin Park Woochul Choi Se-Bum Paik
author_sort	Youngjin Park
title	Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
title_short	Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
title_full	Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
title_fullStr	Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
title_full_unstemmed	Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
title_sort	symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bf7a67b5367c4807be841317031f9def
work_keys_str_mv	AT youngjinpark symmetryoflearningrateinsynapticplasticitymodulatesformationofflexibleandstablememories AT woochulchoi symmetryoflearningrateinsynapticplasticitymodulatesformationofflexibleandstablememories AT sebumpaik symmetryoflearningrateinsynapticplasticitymodulatesformationofflexibleandstablememories
_version_	1718388476889530368

Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories

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