Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes

Ty3 retrotransposon integrates with an exquisite specificity upstream of RNA Polymerase III-transcribed genes, such as transfer RNAs. Here the authors resolve a cryo-EM structure of an active Ty3 intasome in complex with a TFIIIB-bound tRNA promoter, shedding light into the molecular determinants of...

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Autores principales:	Guillermo Abascal-Palacios, Laura Jochem, Carlos Pla-Prats, Fabienne Beuron, Alessandro Vannini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf7b6a981a694ea8b4a21cd408b7a073
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spelling	oai:doaj.org-article:bf7b6a981a694ea8b4a21cd408b7a0732021-12-05T12:22:00ZStructural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes10.1038/s41467-021-27338-w2041-1723https://doaj.org/article/bf7b6a981a694ea8b4a21cd408b7a0732021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27338-whttps://doaj.org/toc/2041-1723Ty3 retrotransposon integrates with an exquisite specificity upstream of RNA Polymerase III-transcribed genes, such as transfer RNAs. Here the authors resolve a cryo-EM structure of an active Ty3 intasome in complex with a TFIIIB-bound tRNA promoter, shedding light into the molecular determinants of harmless retrotransposition.Guillermo Abascal-PalaciosLaura JochemCarlos Pla-PratsFabienne BeuronAlessandro VanniniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guillermo Abascal-Palacios Laura Jochem Carlos Pla-Prats Fabienne Beuron Alessandro Vannini Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
description	Ty3 retrotransposon integrates with an exquisite specificity upstream of RNA Polymerase III-transcribed genes, such as transfer RNAs. Here the authors resolve a cryo-EM structure of an active Ty3 intasome in complex with a TFIIIB-bound tRNA promoter, shedding light into the molecular determinants of harmless retrotransposition.
format	article
author	Guillermo Abascal-Palacios Laura Jochem Carlos Pla-Prats Fabienne Beuron Alessandro Vannini
author_facet	Guillermo Abascal-Palacios Laura Jochem Carlos Pla-Prats Fabienne Beuron Alessandro Vannini
author_sort	Guillermo Abascal-Palacios
title	Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
title_short	Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
title_full	Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
title_fullStr	Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
title_full_unstemmed	Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
title_sort	structural basis of ty3 retrotransposon integration at rna polymerase iii-transcribed genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf7b6a981a694ea8b4a21cd408b7a073
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Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes

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