Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study

Song Zhao, Zhongyuan Ren, Shikai Yu, Chen Chi, Jiamin Tang, Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Jiaxin Li, Yawei Xu, Yi Zhang Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of ChinaCorrespondence: Yi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhao S, Ren Z, Yu S, Chi C, Tang J, Maimaitiaili R, Teliewubai J, Li J, Xu Y, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lipid accumulation product target organ damage elderly Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/bf7c6459d0c44a53970a55529174a20c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf7c6459d0c44a53970a55529174a20c
record_format	dspace
spelling	oai:doaj.org-article:bf7c6459d0c44a53970a55529174a20c2021-12-02T18:51:31ZAssociation Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study1178-1998https://doaj.org/article/bf7c6459d0c44a53970a55529174a20c2021-10-01T00:00:00Zhttps://www.dovepress.com/association-between-lipid-accumulation-product-and-target-organ-damage-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Song Zhao, Zhongyuan Ren, Shikai Yu, Chen Chi, Jiamin Tang, Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Jiaxin Li, Yawei Xu, Yi Zhang Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of ChinaCorrespondence: Yi Zhang; Yawei XuDepartment of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, People’s Republic of ChinaTel/ Fax +86 18917686332Email yizshcn@gmail.com; xuyawei@tongji.edu.cnIntroduction: Lipid accumulation product (LAP), calculated from waist circumference (WC) and triglycerides (TG), is a novel index that correlates cardiovascular disease. We aimed to investigate the relationship between LAP and target organ damage (TOD) in elderly Chinese community-dwelling individuals.Materials and Methods: We enrolled 3363 participants whose age was ≥ 65 years old. TOD, including left ventricular hypertrophy (LVH), arterial stiffness (AS), lower extremity atherosclerotic (LEA), micro-albuminuria (MAU) and chronic kidney disease (CKD), was measured using standard methods. LAP was calculated as (WC– 65) × TG in men and (WC– 58) × TG in women. Both quartiles and continuation of LAP were analyzed.Results: Age-sex adjusted partial correlation analysis showed that LAP was significantly associated with CVD risk factors. With the first quartile (Q1) as a reference, in univariate logistic regression, the fourth quartile (Q4) of LAP was associated with all TOD. In multivariate model, Q4 of LAP was only associated with an increased risk of AS (odds ratio (OR) = 1.88, 95% confidence interval (CI): 1.37– 2.58, Pfor trend< 0.001), MAU (OR = 1.33, 95% CI: 1.01– 1.75, Pfor trend= 0.02) and CKD (OR = 2.39, 95% CI: 1.39– 4.12, Pfor trend< 0.001). But, Q4 of LAP was not associated with an increased risk of LVH (OR = 1.19, 95% CI: 0.85– 1.65, Pfor trend= 0.25) or LEA (OR = 0.87, 95% CI: 0.58– 1.29, Pfor trend= 0.96). Similar associations were found when analyzed continuously.Conclusion: The novel metabolic parameter LAP is significantly and independently associated with an increased risk of arterial stiffness, chronic kidney disease and micro-albuminuria in Chinese community-dwelling elderly individuals.Keywords: lipid accumulation product, target organ damage, elderlyZhao SRen ZYu SChi CTang JMaimaitiaili RTeliewubai JLi JXu YZhang YDove Medical Pressarticlelipid accumulation producttarget organ damageelderlyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1769-1776 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid accumulation product target organ damage elderly Geriatrics RC952-954.6
spellingShingle	lipid accumulation product target organ damage elderly Geriatrics RC952-954.6 Zhao S Ren Z Yu S Chi C Tang J Maimaitiaili R Teliewubai J Li J Xu Y Zhang Y Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study
description	Song Zhao, Zhongyuan Ren, Shikai Yu, Chen Chi, Jiamin Tang, Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Jiaxin Li, Yawei Xu, Yi Zhang Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of ChinaCorrespondence: Yi Zhang; Yawei XuDepartment of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, People’s Republic of ChinaTel/ Fax +86 18917686332Email yizshcn@gmail.com; xuyawei@tongji.edu.cnIntroduction: Lipid accumulation product (LAP), calculated from waist circumference (WC) and triglycerides (TG), is a novel index that correlates cardiovascular disease. We aimed to investigate the relationship between LAP and target organ damage (TOD) in elderly Chinese community-dwelling individuals.Materials and Methods: We enrolled 3363 participants whose age was ≥ 65 years old. TOD, including left ventricular hypertrophy (LVH), arterial stiffness (AS), lower extremity atherosclerotic (LEA), micro-albuminuria (MAU) and chronic kidney disease (CKD), was measured using standard methods. LAP was calculated as (WC– 65) × TG in men and (WC– 58) × TG in women. Both quartiles and continuation of LAP were analyzed.Results: Age-sex adjusted partial correlation analysis showed that LAP was significantly associated with CVD risk factors. With the first quartile (Q1) as a reference, in univariate logistic regression, the fourth quartile (Q4) of LAP was associated with all TOD. In multivariate model, Q4 of LAP was only associated with an increased risk of AS (odds ratio (OR) = 1.88, 95% confidence interval (CI): 1.37– 2.58, Pfor trend< 0.001), MAU (OR = 1.33, 95% CI: 1.01– 1.75, Pfor trend= 0.02) and CKD (OR = 2.39, 95% CI: 1.39– 4.12, Pfor trend< 0.001). But, Q4 of LAP was not associated with an increased risk of LVH (OR = 1.19, 95% CI: 0.85– 1.65, Pfor trend= 0.25) or LEA (OR = 0.87, 95% CI: 0.58– 1.29, Pfor trend= 0.96). Similar associations were found when analyzed continuously.Conclusion: The novel metabolic parameter LAP is significantly and independently associated with an increased risk of arterial stiffness, chronic kidney disease and micro-albuminuria in Chinese community-dwelling elderly individuals.Keywords: lipid accumulation product, target organ damage, elderly
format	article
author	Zhao S Ren Z Yu S Chi C Tang J Maimaitiaili R Teliewubai J Li J Xu Y Zhang Y
author_facet	Zhao S Ren Z Yu S Chi C Tang J Maimaitiaili R Teliewubai J Li J Xu Y Zhang Y
author_sort	Zhao S
title	Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study
title_short	Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study
title_full	Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study
title_fullStr	Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study
title_full_unstemmed	Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study
title_sort	association between lipid accumulation product and target organ damage in elderly population: the northern shanghai study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bf7c6459d0c44a53970a55529174a20c
work_keys_str_mv	AT zhaos associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT renz associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT yus associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT chic associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT tangj associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT maimaitiailir associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT teliewubaij associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT lij associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT xuy associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy AT zhangy associationbetweenlipidaccumulationproductandtargetorgandamageinelderlypopulationthenorthernshanghaistudy
_version_	1718377409353351168

Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study

Ejemplares similares